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Literature summary extracted from

  • Veyradier, A.; Coppo, P.
    ADAMTS13, von Willebrand factor specific cleaving protease (2011), Med. Sci. (Paris), 27, 1097-1105.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.87 von Willebrand factor + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.87 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.87
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.87 blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.87 von Willebrand factor + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.87 a disintegrin and metalloprotease with thrombospondin type 1 repeats 13
-
 Homo sapiens
3.4.24.87 ADAMTS13
-
 Homo sapiens
3.4.24.87 von Willebrand factor specific cleaving protease
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.24.87 malfunction a severe functional deficiency of ADAMTS13 (activity lower than 10%) is associated with thrombotic thrombocytopenic purpura Homo sapiens
3.4.24.87 physiological function multimeric von Willebrand factor is the mediator of both platelet adhesion to the sub-endothelium and platelet aggregation within the microvessels at high shear rates of blood flow. ADAMTS13 regulates von Willebrand factor adhesive capacity by reducing the size of von Willebrand factor multimers Homo sapiens