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Literature summary extracted from

  • Migliori, M.L.; Romanowski, A.; Simonetta, S.H.; Valdez, D.; Guido, M.; Golombek, D.A.
    Daily variation in melatonin synthesis and arylalkylamine N-acetyltransferase activity in the nematode Caenorhabditis elegans (2012), J. Pineal Res., 53, 38-46.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.87 DNA and amino acid sequence determination and analysis, phylogenetic tree Caenorhabditis elegans

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.87 additional information both white and blue light pulses significantly inhibit AA-NAT activity at zeitgeber time ZT18, detailed overview Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.87 acetyl-CoA + serotonin Caenorhabditis elegans
-
 CoA + N-acetylserotonin
-
 ?
2.3.1.87 acetyl-CoA + serotonin Caenorhabditis elegans TJ1060
-
 CoA + N-acetylserotonin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.87 Caenorhabditis elegans G5EDH7 collected from NGM plates seeded with Escherichia coli NA22
-
2.3.1.87 Caenorhabditis elegans TJ1060 G5EDH7 collected from NGM plates seeded with Escherichia coli NA22
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.87 acetyl-CoA + serotonin
-
 Caenorhabditis elegans CoA + N-acetylserotonin
-
 ?
2.3.1.87 acetyl-CoA + serotonin
-
 Caenorhabditis elegans TJ1060 CoA + N-acetylserotonin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.87 AA-NAT
-
 Caenorhabditis elegans

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.87 37
-
 assay at Caenorhabditis elegans

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.87 6.8
-
 assay at Caenorhabditis elegans

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.87 acetyl-CoA
-
 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
2.3.1.87 additional information under light-dark conditions, a rhythmic pattern of melatonin levels occurs with higher levels toward the middle of the night, peaking at zeitgeber time ZT18, and with a minimum value around ZT0-6. AA-NAT activity shows a diurnal and circadian fluctuation with higher levels of activity during the early night, both under light-dark conditions and constant darkness conditions. A peak is found around ZT12 and circadian time CT12. Light acts on AA-NAT through a well-known phototransduction mechanism that originates in the retina, is mediated by the retinohypothalamic tract, and processed in the hypothalamic suprachiasmatic nuclei, SCN, the site of the master circadian clock. From the SCN, the photic message is transduced through the sympathetic nervous system to the pineal, where noradrenergic receptors, among others, control the activity of AA-NAT Caenorhabditis elegans
2.3.1.87 physiological function melatonin influences circadian rhythms and seasonal behavioral changes in vertebrates, it is synthesized from serotonin by N-acetylation by arylalkylamine N-acetyltransferase and O-methylation by N-acetylserotonin methyltransferase, EC 2.1.1.4 Caenorhabditis elegans