Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kang, K.; Lee, K.; Park, S.; Kim, Y.S.; Back, K.
    Enhanced production of melatonin by ectopic overexpression of human serotonin N-acetyltransferase plays a role in cold resistance in transgenic rice seedlings (2010), J. Pineal Res., 49, 176-182.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.87 functional ectopic overexpression of human serotonin N-acetyltransferase under the constitutive ubiquitin promoter in transgenic Oryza sativa cv. Dongjin seedlings using Agrobacterium-mediated gene transformation leading to elevated synthesis of N-acetylserotonin and melatonin in the transgenic rice plants, phenotype, overview Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.87 additional information enhanced production of melatonin by ectopic overexpression of human serotonin N-acetyltransferase plays a role in cold resistance in transgenic rice seedlings. Leaves of transgenic lines S9 and S10 contain approximately 2.5fold and 1.9fold more chlorophyll, respectively, than those of the wild type Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.87 acetyl-CoA + serotonin Homo sapiens
-
 CoA + N-acetylserotonin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.87 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.87 leaf
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.87 acetyl-CoA + serotonin
-
 Homo sapiens CoA + N-acetylserotonin
-
 ?
2.3.1.87 acetyl-CoA + tryptamine
-
 Homo sapiens CoA + N-acetyltryptamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.87 serotonin N-acetyltransferase
-
 Homo sapiens
2.3.1.87 SNA
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.87 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.87 6.8
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.87 acetyl-CoA
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.87 metabolism serotonin N-acetyltransferase is a rate-limiting enzyme in melatonin biosynthesis in vertebrates Homo sapiens
2.3.1.87 physiological function serotonin N-acetyltransferase is responsible for the production of N-acetylserotonin, an intermediate of melatonin biosynthesis. Melatonin, i.e. N-acetyl-5-methoxytryptamine, has multiple functions in vertebrates, including the regulation of circadian rhythms and photoperiodism. Plant melatonin is involved in cold stress Homo sapiens