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Literature summary extracted from

  • Pelayo, J.C.; Poole, D.P.; Steinhoff, M.; Cottrell, G.S.; Bunnett, N.W.
    Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones (2011), J. Physiol., 589, 5213-5230.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.71 PD-069185
-
 Mus musculus
3.4.24.71 SM-19712 ECE-1 inhibitor prevents endosomal substance P degardation. Thus, neurokinin 1 receptor (NK1R) recycling is suppressed by more than 50% Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.71 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.71 intestine
-
 Mus musculus
-
3.4.24.71 neuron myenteric neuron Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.71 Substance P + H2O
-
 Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.71 ECE-1
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.4.24.71 physiological function by degrading substance P and destabilizing endosomal signalosomes, ECE-1 has a dual role in controlling endocytic signalling and trafficking of the NK1R: promoting resensitization of G protein-mediated plasma membrane signalling, and terminating beta-arrestin-mediated endosomal signalling Mus musculus