EC Number | Cloned (Comment) | Organism |
---|---|---|
2.4.1.17 | - |
Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.17 | (R)-7-hydroxywarfarin | substrate (S)-7-hydroxywarfarin, noncompetitive | Homo sapiens | |
2.4.1.17 | (R)-8-hydroxywarfarin | substrate (S)-6-hydroxywarfarin, noncompetitive | Homo sapiens | |
2.4.1.17 | (S)-8-hydroxywarfarin | substrate (R)-8-hydroxywarfarin, noncompetitive | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.1.17 | 0.044 | - |
(R)-7-hydroxywarfarin | isoform UGT1A10, pH 7.6, 37°C | Homo sapiens | |
2.4.1.17 | 0.105 | - |
(R)-8-hydroxywarfarin | isoform UGT1A10, pH 7.6, 37°C | Homo sapiens | |
2.4.1.17 | 0.13 | - |
(R)-7-hydroxywarfarin | isoform UGT1A1, pH 7.6, 37°C | Homo sapiens | |
2.4.1.17 | 0.139 | - |
(S)-8-hydroxywarfarin | isoform UGT1A10, pH 7.6, 37°C | Homo sapiens | |
2.4.1.17 | 0.16 | - |
(S)-7-hydroxywarfarin | isoform UGT1A10, pH 7.6, 37°C | Homo sapiens | |
2.4.1.17 | 0.21 | - |
(R)-6-hydroxywarfarin | isoform UGT1A10, pH 7.6, 37°C | Homo sapiens | |
2.4.1.17 | 0.23 | - |
(S)-7-hydroxywarfarin | isoform UGT1A1, pH 7.6, 37°C | Homo sapiens | |
2.4.1.17 | 0.36 | - |
(S)-6-hydroxywarfarin | isoform UGT1A10, pH 7.6, 37°C | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.17 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.1.17 | liver | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.17 | (R)-6-hydroxywarfarin + UDP-alpha-D-glucuronate | - |
Homo sapiens | (R)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP | - |
? | |
2.4.1.17 | (R)-7-hydroxywarfarin + UDP-alpha-D-glucuronate | - |
Homo sapiens | (R)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP | - |
? | |
2.4.1.17 | (R)-8-hydroxywarfarin + UDP-alpha-D-glucuronate | - |
Homo sapiens | (R)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP | - |
? | |
2.4.1.17 | (S)-6-hydroxywarfarin + UDP-alpha-D-glucuronate | - |
Homo sapiens | (S)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP | - |
? | |
2.4.1.17 | (S)-7-hydroxywarfarin + UDP-alpha-D-glucuronate | - |
Homo sapiens | (S)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP | - |
? | |
2.4.1.17 | (S)-8-hydroxywarfarin + UDP-alpha-D-glucuronate | - |
Homo sapiens | (S)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP | - |
? |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.4.1.17 | 0.333 | - |
isoform UGT1A10, substrate (S)-7-hydroxywarfarin, pH 7.6, 37°C | Homo sapiens | (R)-7-hydroxywarfarin | |
2.4.1.17 | 0.344 | - |
isoform UGT1A10, substrate (R)-8-hydroxywarfarin, pH 7.6, 37°C | Homo sapiens | (S)-8-hydroxywarfarin | |
2.4.1.17 | 0.401 | - |
isoform UGT1A10, substrate (S)-6-hydroxywarfarin, pH 7.6, 37°C | Homo sapiens | (R)-8-hydroxywarfarin |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.4.1.17 | physiological function | isoform UGT1A1 is involved in glucuronidation´of the main warfarin metabolites, including Rac-6- and 7-hydroxywarfarin and their R- and S-enantiomers in the liver | Homo sapiens |