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Literature summary extracted from

  • Yalcin, D.; Bayraktar, O.
    Inhibition of catechol-O-methyltransferase (COMT) by some plant-derived alkaloids and phenolics (2010), J. Mol. Catal. B, 64, 162-166.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.6 3,5-dinitrocatechol uncompetitive inhibitor Sus scrofa domesticus
2.1.1.6 Cistus parviflorus leaf extract mixed type inhibition Sus scrofa domesticus
2.1.1.6 Harmaline
-
 Sus scrofa domesticus
2.1.1.6 harmalol
-
 Sus scrofa domesticus
2.1.1.6 Peganum harmala seed extract mixed type inhibition Sus scrofa domesticus
2.1.1.6 Vitex agnus-cactus leaf extract mixed type inhibition Sus scrofa domesticus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.6 0.0035
-
 S-adenosyl-L-methionine pH 7.4, 37°C Sus scrofa domesticus
2.1.1.6 0.0064
-
 aesculetin pH 7.4, 37°C Sus scrofa domesticus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.6 Sus scrofa domesticus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.6 commercial preparation Sus scrofa domesticus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.6 liver
-
 Sus scrofa domesticus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.6 0.00107
-
 pH 7.4, 37°C Sus scrofa domesticus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.6 aesculetin + S-adenosyl-L-methionine
-
 Sus scrofa domesticus scopoletin + S-adenosyl-L-homocysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.6 catechol-O-methyltransferase
-
 Sus scrofa domesticus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.6 0.0000456
-
 3,5-dinitrocatechol pH 7.4, 37°C Sus scrofa domesticus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.1.1.6 0.00004418
-
 pH 7.4, 37°C Sus scrofa domesticus 3,5-dinitrocatechol
2.1.1.6 0.00457
-
 pH 7.4, 37°C Sus scrofa domesticus Harmaline
2.1.1.6 0.01319
-
 pH 7.4, 37°C Sus scrofa domesticus harmalol