Literature summary extracted from
Liu, B.; Yildirir, G.; Wang, J.; Tolun, G.; Griffith, J.D.; Englund, P.T.
TbPIF1, a Trypanosoma brucei mitochondrial DNA helicase, is essential for kinetoplast minicircle replication (2010), J. Biol. Chem., 285, 7056-7066.
Localization
EC Number |
Localization |
Comment |
Organism |
GeneOntology No. |
Textmining |
---|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
5.6.2.3 |
Trypanosoma brucei |
Q384Y1 |
- |
- |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
5.6.2.3 |
TbPIF1 |
- |
Trypanosoma brucei |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
5.6.2.3 |
malfunction |
RNAi of TbPIF1 causes a growth defect and kinetoplast DNA loss. Minicircle replication intermediates decrease during RNAi, and there is an accumulation of multiply interlocked, covalently closed minicircle dimers (fraction U) |
Trypanosoma brucei |
5.6.2.3 |
physiological function |
TbPIF1 functions in minicircle replication |
Trypanosoma brucei |