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Literature summary extracted from

  • Alderwick, L.J.; Seidel, M.; Sahm, H.; Besra, G.S.; Eggeling, L.
    Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis (2006), J. Biol. Chem., 281, 15653-15661.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.46 expressed in a Corynebacterium glutamicum AftA-deficient mutant strain and in Escherichia coli C43 (DE3) cells Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.46 additional information not inhibited by ethambutol Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.46 Mycobacterium tuberculosis
-
-
-
2.4.2.46 Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.46 beta-D-arabinofuranosyl-1-monophosphoryldecaprenol + galactan the reaction catalyzed by the enzyme is the transfer of arabinofuranose from beta-D-arabinofuranosyl-1-monophosphoryldecaprenol to galactan Mycobacterium tuberculosis ?
-
 ?
2.4.2.46 beta-D-arabinofuranosyl-1-monophosphoryldecaprenol + galactan the reaction catalyzed by the enzyme is the transfer of arabinofuranose from beta-D-arabinofuranosyl-1-monophosphoryldecaprenol to galactan Mycobacterium tuberculosis H37Rv ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.46 AftA
-
 Mycobacterium tuberculosis
2.4.2.46 arabinofuranosyltransferase A
-
 Mycobacterium tuberculosis
2.4.2.46 Rv3792
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.4.2.46 malfunction a deletion of the AftA gene leads to complete absence of arabinose resulting in a truncated cell wall structure possessing only a galactan core with a concomitant loss of cell wall-bound mycolates Mycobacterium tuberculosis
2.4.2.46 physiological function the enzyme is involved in cell wall arabinan biosynthesis Mycobacterium tuberculosis