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Literature summary extracted from

  • Huang, H.; Scherman, M.S.; DHaeze, W.; Vereecke, D.; Holsters, M.; Crick, D.C.; McNeil, M.R.
    Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-alpha-D-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-D-arabinose synthesis (2005), J. Biol. Chem., 280, 24539-24543.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.4.2.45 medicine the enzyme is a good target for the development of tuberculosis drugs Mycobacterium tuberculosis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.45 expressed in Escherichia coli ER2566 cells Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.45 membrane
-
 Mycobacterium tuberculosis 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.45 30000
-
 x * 30000, SDS-PAGE Mycobacterium tuberculosis
2.4.2.45 33000
-
 x * 33000, estimated from amino acid sequence Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.45 Mycobacterium tuberculosis P9WFR5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.45 trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Mycobacterium tuberculosis trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.45 ? x * 30000, SDS-PAGE Mycobacterium tuberculosis
2.4.2.45 ? x * 33000, estimated from amino acid sequence Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
2.4.2.45 5-phospho-alpha-D-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase
-
 Mycobacterium tuberculosis
2.4.2.45 DPPR synthase
-
 Mycobacterium tuberculosis
2.4.2.45 Rv3806c
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.4.2.45 physiological function the enzyme is essential for the growth of Mycobacterium tuberculosis Mycobacterium tuberculosis