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Literature summary extracted from

  • Sato, S.; Murakami, M.; Yoshimura, T.; Hemmi, H.
    Specific partial reduction of geranylgeranyl diphosphate by an enzyme from the thermoacidophilic archaeon Sulfolobus acidocaldarius yields a reactive prenyl donor, not a dead-end product (2008), J. Bacteriol., 190, 3923-3929.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.7.11 expression in Escherichia coli Sulfolobus acidocaldarius

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.7.11 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor Sulfolobus acidocaldarius the enzyme is involved in the biosynthesis of archaeal membrane lipids 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor
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Organism

EC Number Organism UniProt Comment Textmining
1.3.7.11 Sulfolobus acidocaldarius Q4JA33
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Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.7.11
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 Sulfolobus acidocaldarius

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.7.11 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor the enzyme is involved in the biosynthesis of archaeal membrane lipids Sulfolobus acidocaldarius 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor
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 ?
1.3.7.11 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor most preferred substrate. Since the physiological reducing agents for the enzyme remains unknown, sodium dithionite is used as acceptor Sulfolobus acidocaldarius 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor
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 ?
1.3.7.11 3-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor activity is comparable to the activity with 2,3-di-O-geranylgeranyl-sn-glycerol 1-phosphate as substrate Sulfolobus acidocaldarius 3-O-phytyl-sn-glycerol 1-phosphate + acceptor
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 ?
1.3.7.11 geranylgeranyl diphosphate + reduced acceptor the enzyme does not accept NADPH. Since the physiological reducing agents for the enzyme remains unknown, sodium dithionite is used as acceptor. Geranylgeranyl diphosphate is partially reduced to phytyl diphosphate with 10% of the activity compared to the complete reduction of 2,3-di-O-phytanyl-sn-glycerol 1-phosphate Sulfolobus acidocaldarius phytyl diphosphate + acceptor
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.7.11 geranylgeranyl reductase
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 Sulfolobus acidocaldarius

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.7.11 flavin the enzyme contains a flavin coenzyme Sulfolobus acidocaldarius

General Information

EC Number General Information Comment Organism
1.3.7.11 physiological function the enzyme is involved in the biosynthesis of archaeal membrane lipids Sulfolobus acidocaldarius