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Literature summary extracted from

  • Schaefer, K.; Albers, J.; Sindhuwinata, N.; Peters, T.; Meyer, B.
    A new concept for glycosyltransferase inhibitors: nonionic mimics of the nucleotide donor of the human blood group B galactosyltransferase (2012), ChemBioChem, 13, 443-450.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.37 9-(D-1-deoxy-arabinit-1-yl)-1,3,7-trihydropurine-2,6,8-trione
-
 Homo sapiens
2.4.1.37 9-D-ribityl-1,3,7-trihydropurine-2,6,8-trione
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.37 Mg2+ activity depends on a bivalent cation Homo sapiens
2.4.1.37 Mn2+ activity depends on a bivalent cation Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.37 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.37 UDP-alpha-D-galactose + alpha-L-Fuc-(1-2)-beta-D-Gal-octyl
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.37 GTB
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.37 0.361
-
 9-D-ribityl-1,3,7-trihydropurine-2,6,8-trione pH 7.0, 37°C Homo sapiens
2.4.1.37 0.571
-
 9-(D-1-deoxy-arabinit-1-yl)-1,3,7-trihydropurine-2,6,8-trione pH 7.0, 37°C Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.1.37 1.2
-
 pH 7.0, 37°C Homo sapiens 9-D-ribityl-1,3,7-trihydropurine-2,6,8-trione
2.4.1.37 1.9
-
 pH 7.0, 37°C Homo sapiens 9-(D-1-deoxy-arabinit-1-yl)-1,3,7-trihydropurine-2,6,8-trione