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Literature summary extracted from

  • Bobenchik, A.M.; Choi, J.Y.; Mishra, A.; Rujan, I.N.; Hao, B.; Voelker, D.R.; Hoch, J.C.; Mamoun, C.B.
    Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay (2010), BMC Biochem., 11, 4-4.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.103 expressed in Escherichia coli BL21-Codon-Plus cells Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.103 amodiaquine complete inhibition at 0.025 mM Plasmodium falciparum
2.1.1.103 dodecyltrimethylammonium 25% inhibition at 0.5 mM Plasmodium falciparum
2.1.1.103 hexadecyltrimethylammonium about 50% inhibition at 0.1 mM Plasmodium falciparum
2.1.1.103 miltefosine about 60% inhibition at 0.1 mM, complete loss of activity at 0.15 mM Plasmodium falciparum
2.1.1.103 additional information not inhibited by 2,3-dichloro-methylbenzyl-amine, chloroquine, and dodecyltrimethylammonium at concentrations up to 0.1 mM Plasmodium falciparum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.103 Plasmodium falciparum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.103 Ni-NTA column chromatography, gel filtration Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.103 3 S-adenosyl-L-methionine + phosphoethanolamine
-
 Plasmodium falciparum 3 S-adenosyl-L-homocysteine + phosphocholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.103 phosphoethanolamine methyltransferase
-
 Plasmodium falciparum
2.1.1.103 PMT
-
 Plasmodium falciparum