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Literature summary extracted from

  • Lee, J.H.; Choi, Y.J.; Heo, S.H.; Lee, J.M.; Cho, J.Y.
    Tumor necrosis factor-alpha converting enzyme (TACE) increases RANKL expression in osteoblasts and serves as a potential biomarker of periodontitis (2011), BMB Rep., 44, 473-477.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.24.86 medicine the enzyme serves as a potential biomarker of periodontitis Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.86 membrane
-
 Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.86 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.86 gingiva
-
 Homo sapiens
-
3.4.24.86 gingival fluid
-
 Homo sapiens
-
3.4.24.86 osteoblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.86 proTNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.86 ADAM17
-
 Homo sapiens
3.4.24.86 TACE
-
 Homo sapiens
3.4.24.86 TNF-alpha converting enzyme
-
 Homo sapiens
3.4.24.86 tumor necrosis factor-alpha converting enzyme
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.24.86 physiological function the enzyme increases receptor activator of nuclear factor-kappaB ligand secretion and decreases osteoprotegerin protein expression in osteoblasts Homo sapiens