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Literature summary extracted from

  • Iwase, N.; Kudo, F.; Yamauchi, N.; Kakinuma, K.
    Substrate specificity of 2-deoxy-scyllo-inosose synthase, the starter enzyme for 2-deoxystreptamine biosynthesis, toward deoxyglucose-6-phosphates and proposed mechanism (1998), Biosci. Biotechnol. Biochem., 62, 2396-2407.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.3.124 Co2+ required Niallia circulans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.124 D-glucose 6-phosphate Niallia circulans carbocycle formation 2-deoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 D-glucose 6-phosphate Niallia circulans SANK72073 carbocycle formation 2-deoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 additional information Niallia circulans the hydroxy group at C-4 is essential for enzyme activity, while the hydroxy groups at C-2 and C-3 are significant for efficial transformation of natural glucose 6-phosphate, but not essential for the reaction catalysis at the active site of enzyme, no activity with 4-deoxy-glucose 6-phosphate, substrate specificity, overview ?
-
 ?
4.2.3.124 additional information Niallia circulans SANK72073 the hydroxy group at C-4 is essential for enzyme activity, while the hydroxy groups at C-2 and C-3 are significant for efficial transformation of natural glucose 6-phosphate, but not essential for the reaction catalysis at the active site of enzyme, no activity with 4-deoxy-glucose 6-phosphate, substrate specificity, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.124 Niallia circulans Q9S5E2
-
-
4.2.3.124 Niallia circulans SANK72073 Q9S5E2
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.2.3.124 D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate catalyric reaction mechanism and substrate specificity, overview Niallia circulans
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.124 2-deoxy-D-glucose 6-phosphate low activity Niallia circulans 2,5-dideoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 2-deoxy-D-glucose 6-phosphate low activity Niallia circulans SANK72073 2,5-dideoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 3-deoxy-D-glucose 6-phosphate low activity Niallia circulans 2,4-dideoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 3-deoxy-D-glucose 6-phosphate low activity Niallia circulans SANK72073 2,4-dideoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 D-glucose 6-phosphate carbocycle formation Niallia circulans 2-deoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 D-glucose 6-phosphate carbocycle formation Niallia circulans SANK72073 2-deoxy-L-scyllo-inosose + phosphate
-
 ?
4.2.3.124 additional information the hydroxy group at C-4 is essential for enzyme activity, while the hydroxy groups at C-2 and C-3 are significant for efficial transformation of natural glucose 6-phosphate, but not essential for the reaction catalysis at the active site of enzyme, no activity with 4-deoxy-glucose 6-phosphate, substrate specificity, overview Niallia circulans ?
-
 ?
4.2.3.124 additional information substrate specificity of 2-deoxy-scyllo-inosose synthase towards deoxyglucose 6-phosphates and proposed mechanism Niallia circulans ?
-
 ?
4.2.3.124 additional information the hydroxy group at C-4 is essential for enzyme activity, while the hydroxy groups at C-2 and C-3 are significant for efficial transformation of natural glucose 6-phosphate, but not essential for the reaction catalysis at the active site of enzyme, no activity with 4-deoxy-glucose 6-phosphate, substrate specificity, overview Niallia circulans SANK72073 ?
-
 ?
4.2.3.124 additional information substrate specificity of 2-deoxy-scyllo-inosose synthase towards deoxyglucose 6-phosphates and proposed mechanism Niallia circulans SANK72073 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.3.124 DOIS
-
 Niallia circulans

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.2.3.124 37
-
 assay at Niallia circulans

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.3.124 NAD+ required Niallia circulans

General Information

EC Number General Information Comment Organism
4.2.3.124 metabolism 2-deoxy-scyllo-inosose synthase is the starter enzyme for 2-deoxystreptamine biosynthesis. 2-Deoxystreptamine is the aglycon of clinically important aminocyclitol antibiotics Niallia circulans