EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.275 | 4-methoxyphenyl palmitoylsulfamate | good antimicrobial activity against both Staphylococcus aureus and Bacillus anthracis | Bacillus anthracis | |
2.3.1.275 | 4-methoxyphenyl palmitoylsulfamate | good antimicrobial activity against both Staphylococcus aureus and Bacillus anthracis | Staphylococcus aureus | |
2.3.1.275 | 4-methoxyphenyl undec-10-enoylsulfamate | broad antimicrobial profile with good activity against multiple species of Gram-positive bacteria | Bacillus anthracis | |
2.3.1.275 | 4-methoxyphenyl undec-10-enoylsulfamate | broad antimicrobial profile with good activity against multiple species of Gram-positive bacteria | Staphylococcus aureus | |
2.3.1.275 | additional information | data suggest that acylsulfamate inhibitors may have off-target effects on bacterial membrane function | Bacillus anthracis | |
2.3.1.275 | phenyl (8-phenyloctanoyl)sulfamate | good antimicrobial activity against both Staphylococcus aureus and Bacillus anthracis. Compound causes an abrupt cessation of cell growth and inhibits inhibits protein, DNA and RNA synthesis in Bacillus anthracis Sterne | Bacillus anthracis | |
2.3.1.275 | phenyl (8-phenyloctanoyl)sulfamate | good antimicrobial activity against both Staphylococcus aureus and Bacillus anthracis. Staphylococcus aureus cell growth does not immediately cease following addition, but slows down over approximately 2 h before stopping completely. Compound causes a concentration dependent decrease in acetate incorporation into fatty acids and membrane phospholipids | Staphylococcus aureus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.275 | Bacillus anthracis | - |
- |
- |
2.3.1.275 | Staphylococcus aureus | - |
- |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.275 | PlsY | - |
Staphylococcus aureus |
2.3.1.275 | PlsY1 | - |
Bacillus anthracis |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.275 | 0.008 | - |
pH 7.4, 37°C | Staphylococcus aureus | 4-methoxyphenyl palmitoylsulfamate | |
2.3.1.275 | 0.025 | - |
pH 7.4, 37°C | Staphylococcus aureus | phenyl (8-phenyloctanoyl)sulfamate | |
2.3.1.275 | 0.027 | - |
pH 7.4, 37°C | Staphylococcus aureus | 4-methoxyphenyl undec-10-enoylsulfamate |