Literature summary extracted from

Feng, Y.; Bowden, B.; Kapoor, V.
Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata (2012), Bioorg. Med. Chem. Lett., 22, 3398-3401.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.7.1.3	lanthellamide	about 60% residual activity at 1 mM, about 80% residual activity at 0.5 mM, slight inhibition at 0.125 mM	Rattus norvegicus
3.7.1.3	additional information	lanthellamide does not inhibit the enzyme at concentrations up to 0.0625 mM	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.7.1.3	Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.7.1.3	3-hydroxy-L-kynurenine + H2O	-	Rattus norvegicus	3-hydroxyanthranilate + L-alanine	-	?
3.7.1.3	L-kynurenine + H2O	-	Rattus norvegicus	anthranilate + L-alanine	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.7.1.3	Kynase	-	Rattus norvegicus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
3.7.1.3	pyridoxal 5'-phosphate	-	Rattus norvegicus

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Release 2023.1 (January 2023)