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Literature summary extracted from

  • Milek, M.; Smid, A.; Tamm, R.; Kuzelicki, N.K.; Metspalu, A.; Mlinaric-Rascan, I.
    Post-translational stabilization of thiopurine S-methyltransferase by S-adenosyl-L-methionine reveals regulation of TPMT*1 and *3C allozymes (2012), Biochem. Pharmacol., 83, 969-976.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.1.1.67 S-adenosyl-L-methionine is responsible for direct stabilization of the enzyme Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.67 35000
-
 x * 35000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.67 erythrocyte
-
 Homo sapiens
-
2.1.1.67 HEK-293 cell
-
 Homo sapiens
-
2.1.1.67 HeLa cell
-
 Homo sapiens
-
2.1.1.67 Hep-G2 cell
-
 Homo sapiens
-
2.1.1.67 MOLT cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.67 ? x * 35000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.1.1.67 TPMT
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.1.1.67 Homo sapiens the restriction of L-methionine in cell growth media reversibly decreases enzyme activity and protein levels down