Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • O’Neill, S.M.; Houck, K.L.; Yun, J.K.; Fox, T.E.; Kester, M.
    AP-1 binding transcriptionally regulates human neutral ceramidase (2011), Arch. Biochem. Biophys., 511, 31-39.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.23 ceramide + H2O Homo sapiens
-
 sphingosine + fatty acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.23 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.23 coronary artery smooth muscle cell
-
 Homo sapiens
-
3.5.1.23 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.23 ceramide + H2O
-
 Homo sapiens sphingosine + fatty acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.23 nCDase
-
 Homo sapiens
3.5.1.23 neutral ceramidase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.5.1.23 Homo sapiens treatment with fetal bovine serum (FBS) induces approximately a 60% increase in nCDase mRNA expression in coronary artery smooth muscle cells after 6 h. FBS elevates nCDase mRNA expression approximately 35% in HEK-293. cells c-Jun/AP-1 signaling in part regulates serum-induced human nCDase gene transcription up