Literature summary extracted from

Sanchez-Quitian, Z.A.; Timmers, L.F.; Caceres, R.A.; Rehm, J.G.; Thompson, C.E.; Basso, L.A.; de Azevedo, W.F.; Santos, D.S.
Crystal structure determination and dynamic studies of Mycobacterium tuberculosis cytidine deaminase in complex with products (2011), Arch. Biochem. Biophys., 509, 108-115.

Application

EC Number	Application	Comment	Organism
3.5.4.5	drug development	CDA is a target for development of specific enzyme inhibitors with potential anti-proliferative activity on cell growth of Mycobacterium tuberculosis, the major causative agent of tuberculosis	Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
3.5.4.5	purified CDA in complex with uridine and deoxyuridine, hanging drop vapor diffusion method, 0.002 ml of 12 mg/ml protein in 20 mM Tris-HCl pH 7.5 is mixed with 0.002 ml of reservoir solution containing 0.1 M HEPES, pH 7.5 and 4.3 M sodium chloride, ligands uridine and deoxyuridine are added by soaking method, X-ray diffractiuon structure determination and analysis at 2.4 and 1.9 A resolution,molecular dynamics simulation, structure modeling	Mycobacterium tuberculosis

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.4.5	Mycobacterium tuberculosis	P9WPH3	-	-
3.5.4.5	Mycobacterium tuberculosis H37Rv	P9WPH3	-	-

Subunits

EC Number	Subunits	Comment	Organism
3.5.4.5	tetramer	-	Mycobacterium tuberculosis

Synonyms

EC Number	Synonyms	Comment	Organism
3.5.4.5	CDA	-	Mycobacterium tuberculosis

General Information

EC Number	General Information	Comment	Organism
3.5.4.5	metabolism	cytidine deaminase is a key enzyme in the pyrimidine salvage pathway	Mycobacterium tuberculosis
3.5.4.5	physiological function	cytidine amidase is involved in the hydrolytic deamination of cytidine or 2'-deoxycytidine to uridine or 2'-deoxyuridine, determination of the protein-ligand recognition process, respectively	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)