EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.56 | dexamethasone | induces activity | Rattus norvegicus | |
1.14.14.56 | pregnenolone 16alpha-carbonitrile | induces activity | Rattus norvegicus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.14.56 | expression in insect cells | Homo sapiens |
1.14.14.56 | expression in insect cells | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.56 | ketoconazole | significant inhibition | Homo sapiens | |
1.14.14.56 | ketoconazole | significant inhibition | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.14.56 | 0.45 | - |
1,4-cineole | pH 7.4, 37°C | Homo sapiens | |
1.14.14.56 | 1.033 | - |
1,4-cineole | pH 7.4, 37°C, animals treated with pregnenolone 16alpha-carbonitrile | Rattus norvegicus | |
1.14.14.56 | 1.123 | - |
1,4-cineole | pH 7.4, 37°C, animals treated with dexamethasone | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.56 | Homo sapiens | - |
- |
- |
1.14.14.56 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.56 | 1,4-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2 | - |
Homo sapiens | 2-exo-hydroxy-1,4-cineole + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.56 | 1,4-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2 | - |
Rattus norvegicus | 2-exo-hydroxy-1,4-cineole + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.56 | 1,8-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2 | - |
Homo sapiens | 2-exo-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.56 | 1,8-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2 | - |
Rattus norvegicus | 2-exo-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.56 | CYP3A4 | - |
Homo sapiens |