Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Xie, L.S.; Huang, J.; Qin, W.; Fan, J.M.
    Immunoglobulin A1 protease: a new therapeutic candidate for immunoglobulin A nephropathy (2010), Nephrology, 15, 584-586.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.72 medicine IgA1 protease may be an effective therapeutic candidate for IgAN by removing the mesangial deposited IgA1 in glomerular mesangium leading to immunoglobulin A nephropathy. The removal of IgA1 by IgA1 protease may separate the IgA1-containing immune complexes thereby eliminating its other components at the same time Haemophilus influenzae
3.4.21.72 medicine IgA1 protease may be an effective therapeutic candidate for IgAN by removing the mesangial deposited IgA1 in glomerular mesangium leading to immunoglobulin A nephropathy. The removal of IgA1 by IgA1 protease may separate the IgA1-containing immune complexes thereby eliminating its other components at the same time Neisseria gonorrhoeae
3.4.21.72 medicine IgA1 protease may be an effective therapeutic candidate for IgAN by removing the mesangial deposited IgA1 in glomerular mesangium leading to immunoglobulin A nephropathy. The removal of IgA1 by IgA1 protease may separate the IgA1-containing immune complexes thereby eliminating its other components at the same time Neisseria meningitidis
3.4.24.13 medicine IgA1 protease may be an effective therapeutic candidate for IgAN by removing the mesangial deposited IgA1 in glomerular mesangium leading to immunoglobulin A nephropathy. The removal of IgA1 by IgA1 protease may separate the IgA1-containing immune complexes thereby eliminating its other components at the same time Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.72 human IgA1 + H2O Haemophilus influenzae IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 ?
-
 ?
3.4.21.72 human IgA1 + H2O Neisseria gonorrhoeae IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 ?
-
 ?
3.4.21.72 human IgA1 + H2O Neisseria meningitidis IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 ?
-
 ?
3.4.24.13 human IgA1 + H2O Streptococcus pneumoniae IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.72 Haemophilus influenzae
-
-
-
3.4.21.72 Neisseria gonorrhoeae
-
-
-
3.4.21.72 Neisseria meningitidis
-
-
-
3.4.24.13 Streptococcus pneumoniae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.72 human IgA1 + H2O IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 Haemophilus influenzae ?
-
 ?
3.4.21.72 human IgA1 + H2O IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 Neisseria gonorrhoeae ?
-
 ?
3.4.21.72 human IgA1 + H2O IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 Neisseria meningitidis ?
-
 ?
3.4.21.72 human IgA1 + H2O human IgA1 possesses a unique hinge region composed of a repeated sequence rich in proline, serine and threonine, which are the specific cleavage sites of IgA1 protease Haemophilus influenzae ?
-
 ?
3.4.21.72 human IgA1 + H2O human IgA1 possesses a unique hinge region composed of a repeated sequence rich in proline, serine and threonine, which are the specific cleavage sites of IgA1 protease Neisseria gonorrhoeae ?
-
 ?
3.4.21.72 human IgA1 + H2O human IgA1 possesses a unique hinge region composed of a repeated sequence rich in proline, serine and threonine, which are the specific cleavage sites of IgA1 protease Neisseria meningitidis ?
-
 ?
3.4.24.13 human IgA1 + H2O IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 Streptococcus pneumoniae ?
-
 ?
3.4.24.13 human IgA1 + H2O human IgA1 possesses a unique hinge region composed of a repeated sequence rich in proline, serine and threonine, which are the specific cleavage sites of IgA1 protease Streptococcus pneumoniae ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.72 IgA1 protease
-
 Haemophilus influenzae
3.4.21.72 IgA1 protease
-
 Neisseria gonorrhoeae
3.4.21.72 IgA1 protease
-
 Neisseria meningitidis
3.4.21.72 immunoglobulin A1 protease
-
 Haemophilus influenzae
3.4.21.72 immunoglobulin A1 protease
-
 Neisseria gonorrhoeae
3.4.21.72 immunoglobulin A1 protease
-
 Neisseria meningitidis
3.4.24.13 IgA1 protease
-
 Streptococcus pneumoniae
3.4.24.13 immunoglobulin A1 protease
-
 Streptococcus pneumoniae