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Literature summary extracted from

  • Chao, S.C.; Hu, D.N.; Yang, P.Y.; Lin, C.Y.; Yang, S.F.
    Overexpression of urokinase-type plasminogen activator in pterygia and pterygium fibroblasts (2011), Mol. Vis., 17, 23-31.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.73 plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.73 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.73 pterygium overexpression of uPA mRNA in various stages of surgically excised pterygia specimens and cultured pterygium fibroblasts, expression is increased significantly following the progression of the pterygium, quantitative real-time PCR analysis, overview Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.73 plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.73 uPA
-
 Homo sapiens
3.4.21.73 Urokinase-type plasminogen activator
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.73 physiological function urokinase-type plasminogen activator is a protease involved in tissue remodeling and cell migration, increased expression of uPA in pterygium may covert plasminogen to plasmin, degrade extracellular matrixes, stimulate cell migration, induce angiogenesis, and plays an important role in the development and progression of pterygium Homo sapiens