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Literature summary extracted from

  • Franco, G.C.; Kajiya, M.; Nakanishi, T.; Ohta, K.; Rosalen, P.L.; Groppo, F.C.; Ernst, C.W.; Boyesen, J.L.; Bartlett, J.D.; Stashenko, P.; Taubman, M.A.; Kawai, T.
    Inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo (2011), Exp. Cell Res., 317, 1454-1464.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.35 doxycycline inhibitory mechanism and effect on osteoclastogenesis signaling induced by RANKL, both in vitro and in vivo, overview. Although Dox inhibits RANKL-induced osteoclastogenesis and down-modulates the mRNA expression of functional osteoclast markers, it neither affects RANKL-induced MAPKs phosphorylation nor NFATc1 gene expression in RAW264.7 monocytic cells Mus musculus
3.4.24.35 MMP-9 inhibitor I
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.35 extracellular
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.35 Gelatin + H2O Mus musculus
-
 ?
-
 ?
3.4.24.35 Gelatin + H2O Mus musculus BALB/c
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.35 Mus musculus
-
-
-
3.4.24.35 Mus musculus BALB/c
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.35 bone marrow-derived monocyte-macrophage cell
-
 Mus musculus
-
3.4.24.35 commercial preparation
-
 Mus musculus
-
3.4.24.35 monocyte
-
 Mus musculus
-
3.4.24.35 RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.35 Gelatin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.35 Gelatin + H2O
-
 Mus musculus BALB/c ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.35 matrix metalloproteinase-9
-
 Mus musculus
3.4.24.35 MMP9
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.4.24.35 Mus musculus auto-amplified NFATc1 plays a key role in upregulating MMP-9 up

General Information

EC Number General Information Comment Organism
3.4.24.35 malfunction inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo, overview. Doxycycline treatment abrogates RANKL-induced osteoclastogenesis and TRAP activity in mouse calvaria along with the suppression of MMP9 enzyme activity, again without affecting the expression of MMP9 protein Mus musculus
3.4.24.35 metabolism auto-amplified NFATc1 plays a key role in upregulating expressions of genes required for osteoclastmaturation, such as TRAP, cathepsin K, or MMP-9,which are requisite for the bone resorption processes mediated by mature osteoclasts Mus musculus