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Literature summary extracted from

  • Beaufort, N.; Seweryn, P.; de Bentzmann, S.; Tang, A.; Kellermann, J.; Grebenchtchikov, N.; Schmitt, M.; Sommerhoff, C.P.; Pidard, D.; Magdolen, V.
    Activation of human pro-urokinase by unrelated proteases secreted by Pseudomonas aeruginosa (2010), Biochem. J., 428, 473-482.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.73 plasminogen activator inhibitor 1
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.73 plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.73 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.73 proteolytic modification activation of human pro-urokinase by unrelated proteases secreted by Pseudomonas aeruginosa, e.g. LasB, a thermolysin-like metalloprotease, or protease IV, overview. Activation of pro-urokinase by purified LasB, or by the secretomes of Pseudomonas aeruginosa LasB-expressing or LasB-deficient strains Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.73 commercial preparation recombinant pro-uPA, expressed in Escherichia coli Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.73 benzoyl-beta-Ala-Gly-Arg-4-nitroanilide + H2O
-
 Homo sapiens benzoyl-beta-Ala-Gly-Arg + 4-nitroaniline
-
 ?
3.4.21.73 plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.73 uPA-type Plg activator
-
 Homo sapiens
3.4.21.73 Urokinase
-
 Homo sapiens
3.4.21.73 urokinase-type Plg activator
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.73 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.73 8
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.73 additional information LasB, a thermolysin-like metalloprotease secreted by Pseudomonas aeruginosa, converts the human uPA zymogen into its active form, processes the uPA receptor, inactivates the plasminogen activator inhibitor 1, and activates pro-matrix metalloproteinase 2 Homo sapiens