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Literature summary extracted from

  • Stone, S.J.; Vance, J.E.
    Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2 (1999), Biochem. J., 342, 57-64.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.29 expression in McArdle cell and in ethanolamine-requiring mutant Chinese hamster ovary cells defective in PSS1, EC 2.7.8.29 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.29 Mus musculus Q9Z1X2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.29 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.29 L-1-phosphatidylethanolamine + L-serine
-
 Mus musculus L-1-phosphatidylserine + ethanolamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.29 PSS2
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.8.29 physiological function expression of PSS2 in ethanolamine-requiring mutant Chinese hamster ovary cells defective in PSS1, reverses the ethanolamine auxotrophy. However, the phosphatidylethanolamine content is not normalized unless the culture medium is supplemented with ethanolamine. In both mutant chinese hamster ovary cells and hepatoma cells transfected with PSS2 cDNA the rate of synthesis of phosphatidylserine and phosphatidylserine-derived phosphatidylethanolamine does not exceed that in parental chinese hamster ovary cells or control McArdle cells, respectively. Expression of murine PSS2 in McArdle cells does not inhibit phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway, whereas expression of similar levels of PSS1 activity inhibit this pathway by approx. 50% Mus musculus