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Literature summary extracted from

  • Fratelli, F.; Abrahao-Neto, J.; Caricati, A.T.; Borges, M.M.; Guidolin, R.; Caricati, C.P.
    An alternative method for purifying and detoxifying diphtheria toxin (2011), Toxicon, 57, 1093-1100.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.2.22 22000
-
 1 * 40000 + 1 * 22000, chain B and chain A, SDS-PAGE Corynebacterium diphtheriae
3.2.2.22 40000
-
 1 * 40000 + 1 * 22000, chain B and chain A, SDS-PAGE Corynebacterium diphtheriae

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.22 Corynebacterium diphtheriae
-
-
-
3.2.2.22 Corynebacterium diphtheriae PW-8
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.2.22 Blue Sepharose column chromatography Corynebacterium diphtheriae

Subunits

EC Number Subunits Comment Organism
3.2.2.22 heterodimer 1 * 40000 + 1 * 22000, chain B and chain A, SDS-PAGE Corynebacterium diphtheriae

Synonyms

EC Number Synonyms Comment Organism
3.2.2.22 diphtheria toxin
-
 Corynebacterium diphtheriae

General Information

EC Number General Information Comment Organism
3.2.2.22 physiological function Corynebacterium diphtheriae secretes the diphtheria toxin, a virulence factor that can be lethal to the human organism at doses below 0.0001 mg/kg of body weight. During infections, the toxin binds to the cell membrane and subunit A will enter the cytoplasm and catalyze the ADP-ribosylation and inactivation of elongation factor 2 thus killing the eukaryotic cell by inhibiting ribosomal translocation Corynebacterium diphtheriae