Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Bhattacharya, P.; Sen, N.; Hoyer, P.B.; Keating, A.F.
    Ovarian expressed microsomal epoxide hydrolase: Role in detoxification of 4-vinylcyclohexene diepoxide and regulation by phosphatidylinositol-3 kinase signaling (2011), Toxicol. Appl. Pharmacol., 258, 118-123.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.9 Cyclohexene oxide using a post-natal day 4 Fischer 344 rat whole ovary culture system, inhibition of mEH using cyclohexene oxide during 4-vinylcyclohexene exposure results in a greater loss of primordial and small primary follicles relative to 4-vinylcyclohexene-treated ovaries. Also, relative to controls, mEH mRNA is increased on day 4 of 4-vinylcyclohexene exposure, followed by increased mEH protein after 6 days. Inhibition of PI3K signaling increases mEH mRNA and protein expression Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.9 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.9 7,12-dimethylbenz[a]anthracene + 3 H2O Rattus norvegicus
-
 7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxide
-
 ?
3.3.2.9 cis-stilbene oxide + H2O Rattus norvegicus
-
 (+)-(1R,2R)-1,2-diphenylethane-1,2-diol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.9 Mus musculus
-
-
-
3.3.2.9 Rattus norvegicus
-
-
-
3.3.2.9 Rattus norvegicus P07687
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.9 ovary
-
 Rattus norvegicus
-
3.3.2.9 ovary exposure to 4-vinylcyclohexene results in increased mRNA and protein expression of microsomal epoxide hydrolase, and an inactive tetrol metabolite 4-(1,2-dihydroxy)ethyl-1,2-dihydroxycyclohexane can be formed in mouse ovarian follicles, potentially through detoxification action of mEH Mus musculus
-
3.3.2.9 ovary using a post-natal day 4 Fischer 344 rat whole ovary culture system, inhibition of mEH using cyclohexene oxide during 4-vinylcyclohexene exposure results in a greater loss of primordial and small primary follicles relative to 4-vinylcyclohexene-treated ovaries. Also, relative to controls, mEH mRNA is increased on day 4 of 4-vinylcyclohexene exposure, followed by increased mEH protein after 6 days. Inhibition of PI3K signaling increases mEH mRNA and protein expression Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.9 4-vinylcyclohexene + H2O
-
 Rattus norvegicus ?
-
 ?
3.3.2.9 4-vinylcyclohexene + H2O
-
 Mus musculus ? after exposure of ovary to 4-vinylcyclohexene, an inactive tetrol metabolite 4-(1,2-dihydroxy)ethyl-1,2-dihydroxycyclohexane can be formed, potentially through detoxification action of mEH ?
3.3.2.9 7,12-dimethylbenz[a]anthracene + 3 H2O
-
 Rattus norvegicus 7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxide
-
 ?
3.3.2.9 7,12-dimethylbenz[a]anthracene + 3 H2O
-
 Mus musculus 7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxide bioactivation reaction ?
3.3.2.9 cis-stilbene oxide + H2O
-
 Rattus norvegicus (+)-(1R,2R)-1,2-diphenylethane-1,2-diol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.9 mEH
-
 Mus musculus
3.3.2.9 mEH
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
3.3.2.9 Rattus norvegicus enzyme mRNA and protein level do not change until 4 days after 4-vinylcyclohexene diepoxide exposure (0.03 mM) additional information
3.3.2.9 Mus musculus exposure to 4-vinylcyclohexene results in increased mRNA and protein expression of microsomal epoxide hydrolase up
3.3.2.9 Rattus norvegicus inhibition of PI3K signaling increases mEH mRNA and protein expression. In a post-natal day 4 Fischer 344 rat whole ovary culture system, mEH mRNA is increased on day 4 of 4-vinylcyclohexene exposure, followed by increased mEH protein after 6 days up
3.3.2.9 Rattus norvegicus the enzyme's protein level is significantly increased by phosphatidyinositol-3 kinase inhibition by 221% on day 4 and 14% on day 6 relative to control-treated ovaries up