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Literature summary extracted from

  • Damen, J.E.; Liu, L.; Rosten, P.; Humphries, R.K.; Jefferson, A.B.; Majerus, P.W.; Krystal, G.
    The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase (1996), Proc. Natl. Acad. Sci. USA, 93, 1689-1693.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.86 expressed in Escherichia coli BL21(DE3) cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.86 EDTA
-
 Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.86 Mg2+ dependent on Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.86 145000
-
 gel filtration Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.86 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.86 phosphoprotein tyrosine-phosphorylated protein Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.86 B6SUtA1 cell
-
 Mus musculus
-
3.1.3.86 bone marrow
-
 Mus musculus
-
3.1.3.86 lung
-
 Mus musculus
-
3.1.3.86 skeletal muscle
-
 Mus musculus
-
3.1.3.86 spleen
-
 Mus musculus
-
3.1.3.86 testis
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.86 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
-
 Mus musculus 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
3.1.3.86 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Mus musculus 1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.86 SH2-containing inositol phosphatase
-
 Mus musculus
3.1.3.86 Shc-associated p145 protein
-
 Mus musculus
3.1.3.86 SHIP
-
 Mus musculus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.1.3.86 Mus musculus calculated from amino acid sequence
-
 7.8