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Literature summary extracted from

  • Prosser, D.E.; Kaufmann, M.; OLeary, B.; Byford, V.; Jones, G.
    Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone (2007), Proc. Natl. Acad. Sci. USA, 104, 12673-12678.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.15.16 expressed in V79-CYP24 or OK (CCL-1840) cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.15.16 A326G the mutation converts human CYP24A1 from 25-hydroxyvitamin-D3 24-hydroxylase into 25-hydroxyvitamin-D3 23-hydroxylase, generating 1alpha,25-dihydroxyvitamin D3-26,23-lactone Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.16 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.16 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 C24-hydroxylation, the preferred pathway of human CYP24A1 Homo sapiens 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1.14.15.16 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 C23-hydroxylation Homo sapiens 1alpha,25-dihydroxyvitamin D3-26,23-lactone + NADP+ + H2O
-
 ?
1.14.15.16 additional information 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1) is a bifunctional enzyme capable of the 24-hydroxylation of 1alpha,25-dihydroxyvitamin D3, leading to the excretory form, calcitroic acid (calcitetrol), and 23-hydroxylation, culminating in 1alpha,25-dihydroxyvitamin D3-26,23-lactone Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.16 25-hydroxyvitamin D3-24-hydroxylase
-
 Homo sapiens
1.14.15.16 CYP24A1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.16 NADPH
-
 Homo sapiens