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Literature summary extracted from

  • Halimi, Y.; Dessau, M.; Pollak, S.; Ast, T.; Erez, T.; Livnat-Levanon, N.; Karniol, B.; Hirsch, J.; Chamovitz, D.
    COP9 signalosome subunit 7 from Arabidopsis interacts with and regulates the small subunit of ribonucleotide reductase (RNR2) (2011), Plant Mol. Biol., 77, 77-89.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.17.4.2 two-hybrid interaction analysis of CSN7 and RNR2 expressing the vectors under control of the 35S promoter in Nicotiana benthamiana cells, transgenic expression of RNR2 in Arabidopsis thaliana plants Arabidopsis thaliana

Protein Variants

EC Number Protein Variants Comment Organism
1.17.4.2 additional information construction of two T-DNA insertion mutants of the RNR2Tso2, inserted within the coding sequence of the second exon of RNR2Tso2. No plants homozygous for the T-DNA allele are detectable for either allele Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.2 signalosome protein complex COP9 i.e. CSN, is a negative regulator of RNR2 activity in Arabidopsis thaliana. The pleiotropic regulator of plant development and contains eight-subunits, RNR2 binds to the C-terminus of subunit 7, CSN7; i.e. CSN, is a negative regulator of RNR2 activity in Arabidopsis thaliana. The pleiotropic regulator of plant development and contains eight-subunits, RNR2 binds to the C-terminus of subunit 7, CSN7 Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.4.2 cytoplasm the subcellular localization of RNR2 is primarily nuclear in meristematic regions, and cytoplasmic in adult cells. RNR2 is constitutively nuclear in csn7 mutant seedlings Arabidopsis thaliana 5737
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1.17.4.2 nucleus the subcellular localization of RNR2 is primarily nuclear in meristematic regions, and cytoplasmic in adult cells. RNR2 is constitutively nuclear in csn7 mutant seedlings Arabidopsis thaliana 5634
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.4.2 additional information Arabidopsis thaliana the small subunit of RNR2 interacts in planta with the C-terminal section of signalosome protein complex COP9 subunit 7, CSN7, overview ?
-
 ?
1.17.4.2 additional information Arabidopsis thaliana Col-0 the small subunit of RNR2 interacts in planta with the C-terminal section of signalosome protein complex COP9 subunit 7, CSN7, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.2 Arabidopsis thaliana P50651 small subunit C of RNR, RNR2a
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1.17.4.2 Arabidopsis thaliana Q9LSD0 small subunit C of RNR, RNR2tso
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1.17.4.2 Arabidopsis thaliana Col-0 P50651 small subunit C of RNR, RNR2a
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1.17.4.2 Arabidopsis thaliana Col-0 Q9LSD0 small subunit C of RNR, RNR2tso
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Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.4.2 recombinant RNR2 from transgenic Arabidopsis thaliana plants by affinity chromatography Arabidopsis thaliana

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.2 meristem
-
 Arabidopsis thaliana
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1.17.4.2 additional information RNR2Tso2 is more prevalent than RNR2A throughout development and in most organs, suggesting that RNR2Tso2 is the predominant RNR2 in Arabidopsis thaliana. RNR2Tso2 levels are more varied than RNR2A levels in response to environmental changes and exposure to chemicals Arabidopsis thaliana
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.2 additional information the small subunit of RNR2 interacts in planta with the C-terminal section of signalosome protein complex COP9 subunit 7, CSN7, overview Arabidopsis thaliana ?
-
 ?
1.17.4.2 additional information the small subunit of RNR2 interacts in planta with the C-terminal section of signalosome protein complex COP9 subunit 7, CSN7, overview Arabidopsis thaliana Col-0 ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.4.2 ribonucleotide reductase
-
 Arabidopsis thaliana
1.17.4.2 RNR2 small subunit of RNR Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
1.17.4.2 additional information RNR2Tso2 is essential in Col-0 Arabidopsis thaliana