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Literature summary extracted from

  • Lu, J.; Pierce, M.; Franklin, A.; Jilling, T.; Stafforini, D.M.; Caplan, M.
    Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis (2010), Pediatr. Res., 68, 225-230.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.47 additional information generation of enzyme-deficient PAF-AH-/- mice by targeted disruption of the mouse PAF-AH gene. Mortality rates are significantly lower in PAF-AH-/- pups compared to wild-type controls before 24 hours of life but surviving PAF-AH-/- animals are more susceptible to necrotizing enterocolitis, NEC, development compared to wild-type controls Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.47 extracellular
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 additional information Mus musculus PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity ?
-
 ?
3.1.1.47 additional information Mus musculus C57/BL6J PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Mus musculus
-
-
-
3.1.1.47 Mus musculus C57/BL6J
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.47 blood serum
-
 Mus musculus
-
3.1.1.47 intestine
-
 Mus musculus
-
3.1.1.47 plasma
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 additional information PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity Mus musculus ?
-
 ?
3.1.1.47 additional information PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity Mus musculus C57/BL6J ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.47 LpPLA2
-
 Mus musculus
3.1.1.47 PAF-acetylhydrolase
-
 Mus musculus
3.1.1.47 PAFAH
-
 Mus musculus
3.1.1.47 PLA2G7
-
 Mus musculus
3.1.1.47 platelet-activating factor acetylhydrolase
-
 Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.47 7.5
-
 assay at Mus musculus

General Information

EC Number General Information Comment Organism
3.1.1.47 malfunction deletion of the plasma form of PAF-AH abolishes expression of serum and intestinal activities. Mortality rates are significantly lower in enzyme-deficient PAF-AH-/- pups compared to wild-type controls before 24 hours of life but surviving PAF-AH-/- animals are more susceptible to necrotizing enterocolitis, NEC, development compared to wild-type controls Mus musculus
3.1.1.47 physiological function the enzyme inactivates platelet-activating factor, PAF. Protective role for endogenous PAF-AH in the development of necrotizing enterocolitis, NEC, and endogenous PAF-AH deficiency may place them at increased risk for disease Mus musculus