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Literature summary extracted from

  • Santos, M.; Toyama, D.; Oliveira, S.; Cotrim, C.; Diz-Filho, E.; Fagundes, F.; Soares, V.; Aparicio, R.; Toyama, M.
    Modulation of the pharmacological activities of secretory phospholipase A2 from Crotalus durissus cascavella induced by naringin (2011), Molecules, 16, 738-761.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 4-bromophenacyl bromide 4-bromophenacyl bromide treatment irreversibly abolishes the neurotoxic effect induced by secretory phospholipase A2 Crotalus durissus cascavella
3.1.1.4 naringin the enzymatic activity of native secretory phospholipase A2 is virtually abolished by treatment with naringin Crotalus durissus cascavella

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.4 28000
-
 2 * 28000, SDS-PAGE Crotalus durissus cascavella
3.1.1.4 28900
-
 2 * 28900, calculated from amino acid sequence Crotalus durissus cascavella

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Crotalus durissus cascavella
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.4 mu-Bondapack C18 column chromatography and Superdex 75 gel filtration Crotalus durissus cascavella

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 venom
-
 Crotalus durissus cascavella
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 4-nitro-3-octanoyloxybenzoic acid + H2O
-
 Crotalus durissus cascavella ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.4 homodimer 2 * 28000, SDS-PAGE Crotalus durissus cascavella
3.1.1.4 homodimer 2 * 28900, calculated from amino acid sequence Crotalus durissus cascavella

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 secretory phospholipase A2
-
 Crotalus durissus cascavella
3.1.1.4 sPLA2
-
 Crotalus durissus cascavella