EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
6.4.1.2 | cytoplasm | - |
Trypanosoma brucei | 5737 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.4.1.2 | Trypanosoma brucei | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.4.1.2 | ATP + acetyl-CoA + HCO3- | - |
Trypanosoma brucei | ADP + malonyl-CoA + phosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
6.4.1.2 | ? | x * about 200000, SDS-PAGE | Trypanosoma brucei |
6.4.1.2 | ? | x * about 243000, estimated from amino acid sequence | Trypanosoma brucei |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.4.1.2 | ACC | - |
Trypanosoma brucei |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
6.4.1.2 | ATP | - |
Trypanosoma brucei | |
6.4.1.2 | biotin | - |
Trypanosoma brucei |
EC Number | General Information | Comment | Organism |
---|---|---|---|
6.4.1.2 | malfunction | in procyclic forms, ACC RNAi results in 50-75% reduction in fatty acid elongation and a 64% reduction in growth in low-lipid media. In bloodstream forms, ACC RNAi results in a minor 15% decrease in fatty acid elongation and no growth defect in culture, even in low-lipid media. ACC RNAi does attenuate virulence in a mouse model of infection | Trypanosoma brucei |
6.4.1.2 | metabolism | ACC is required for elongation of fatty acids, both laurate and myristate are elongated to products up to 18 carbons | Trypanosoma brucei |
6.4.1.2 | physiological function | ACC is required by procyclic forms for growth in culture under lipid-limited conditions and by bloodstream forms for full virulence in mice | Trypanosoma brucei |