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Literature summary extracted from

  • Liu, H.; Kiledjian, M.
    Scavenger decapping activity facilitates 5' to 3' mRNA decay (2005), Mol. Cell. Biol., 25, 9764-9772.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.59 7-methylguanosine 5'-diphosphate + H2O Saccharomyces cerevisiae mRNA degradation occurs through distinct pathways, one primarily from the 5' end of the mRNA and the second from the 3' end. Decay from the 3' end generates the m7G5'ppp5'N cap dinucleotide, which is subsequently hydrolyzed to m7Gp and nucleotidyl 5'-diphosphate in Saccharomyces cerevisiae by a scavenger decapping activity termed Dcs1p 7-methylguanosine 5'-phosphate + phosphate
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 ?
3.6.1.59 m7G5'ppp5'N(3'ppp5'N)n + H2O Saccharomyces cerevisiae n = 1-8, mRNA degradation occurs through distinct pathways, one primarily from the 5' end of the mRNA and the second from the 3' end. Decay from the 3' end generates the m7GpppN cap dinucleotide, which is subsequently hydrolyzed to m7Gp and ppN in Saccharomyces cerevisiae by a scavenger decapping activity termed Dcs1p 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.59 Saccharomyces cerevisiae Q06151
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.59 7-methylguanosine 5'-diphosphate + H2O mRNA degradation occurs through distinct pathways, one primarily from the 5' end of the mRNA and the second from the 3' end. Decay from the 3' end generates the m7G5'ppp5'N cap dinucleotide, which is subsequently hydrolyzed to m7Gp and nucleotidyl 5'-diphosphate in Saccharomyces cerevisiae by a scavenger decapping activity termed Dcs1p Saccharomyces cerevisiae 7-methylguanosine 5'-phosphate + phosphate
-
 ?
3.6.1.59 7-methylguanosine 5'-diphosphate + nucleotidyl 5'-diphosphate + H2O
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 Saccharomyces cerevisiae 7-methylguanosine 5'-phosphate + ?
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 ?
3.6.1.59 m7G5'ppp5'N(3'ppp5'N)n + H2O n = 1-8 Saccharomyces cerevisiae 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n
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 ?
3.6.1.59 m7G5'ppp5'N(3'ppp5'N)n + H2O n = 1-8, mRNA degradation occurs through distinct pathways, one primarily from the 5' end of the mRNA and the second from the 3' end. Decay from the 3' end generates the m7GpppN cap dinucleotide, which is subsequently hydrolyzed to m7Gp and ppN in Saccharomyces cerevisiae by a scavenger decapping activity termed Dcs1p Saccharomyces cerevisiae 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.59 Dcps
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 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
3.6.1.59 malfunction disruption of the DCS1 gene manifests a threefold increase of the TIF51A mRNA half-life. 5' to 3' exoribonucleolytic activity is impeded in the dcs1DELTAstrain, resulting in the accumulation of uncapped mRNA Saccharomyces cerevisiae