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Literature summary extracted from

  • McAtee, B.; Yager, J.
    Manganese superoxide dismutase: Effect of the ala16val polymorphism on protein, activity, and mRNA levels in human breast cancer cell lines and stably transfected mouse embryonic fibroblasts (2010), Mol. Cell. Biochem., 335, 107-118.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.15.1.1 DNA and amino acid sequence determination and analysis, ala16val polymorphism genotyping, overview, stably expression of human MnSOD-A16 and MnSOD-V16 variants in mouse fibroblasts Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.15.1.1 A16V naturally occuring ala16val polymorphism genotyping, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.15.1.1 mitochondrial matrix MnSOD is translated in the cytoplasm and then imported into the mitochondria via a mitochondrial targeting signal Homo sapiens 5759
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.15.1.1 Mn2+ MnSOD Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.15.1.1 2 O2.- + 2 H+ + Homo sapiens
-
 O2 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Homo sapiens P04179
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.15.1.1 breast cancer cell harbors MnSOD with the ala16val polymorphism Homo sapiens
-
1.15.1.1 HCC-38 cell
-
 Homo sapiens
-
1.15.1.1 MCF-7 cell
-
 Homo sapiens
-
1.15.1.1 MDA-MB-231 cell
-
 Homo sapiens
-
1.15.1.1 T-47D cell
-
 Homo sapiens
-
1.15.1.1 ZR-75-1 cell
-
 Homo sapiens
-
1.15.1.1 ZR-75-30 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 2 O2.- + 2 H+ +
-
 Homo sapiens O2 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.15.1.1 manganese superoxide dismutase
-
 Homo sapiens
1.15.1.1 MnSOD
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.15.1.1 malfunction MnSOD ala16val polymorphism is associated with various diseases including breast cancer Homo sapiens