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Literature summary extracted from
- Ferrochelatase is a conserved downstream target of the blue light-sensing White collar complex in fungi (2010), Microbiology, 156, 2393-2407.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.98.1.1 | expressed in a Saccharomyces cerevisiae hem15-deficient strain | Cryptococcus neoformans |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.98.1.1 | mitochondrion | - |
Neurospora crassa | 5739 | - |
| 4.98.1.1 | mitochondrion | - |
Phycomyces blakesleeanus | 5739 | - |
| 4.98.1.1 | mitochondrion | - |
Rhizopus arrhizus | 5739 | - |
| 4.98.1.1 | mitochondrion | - |
Candida albicans | 5739 | - |
| 4.98.1.1 | mitochondrion | - |
Cryptococcus neoformans | 5739 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.98.1.1 | protoporphyrin + Fe2+ | Neurospora crassa | - |
protoheme + H+ | - |
? |  |
| 4.98.1.1 | protoporphyrin + Fe2+ | Phycomyces blakesleeanus | - |
protoheme + H+ | - |
? | |
| 4.98.1.1 | protoporphyrin + Fe2+ | Rhizopus arrhizus | - |
protoheme + H+ | - |
? | |
| 4.98.1.1 | protoporphyrin + Fe2+ | Candida albicans | - |
protoheme + H+ | - |
? | |
| 4.98.1.1 | protoporphyrin + Fe2+ | Cryptococcus neoformans | - |
protoheme + H+ | - |
? | |
| 4.98.1.1 | protoporphyrin + Fe2+ | Phycomyces blakesleeanus NRRL1555 | - |
protoheme + H+ | - |
? | |
| 4.98.1.1 | protoporphyrin + Fe2+ | Rhizopus arrhizus RA 99-880 | - |
protoheme + H+ | - |
? | |
| 4.98.1.1 | protoporphyrin + Fe2+ | Neurospora crassa FGSC 4200 | - |
protoheme + H+ | - |
? | |
| 4.98.1.1 | protoporphyrin + Fe2+ | Cryptococcus neoformans JEC21 | - |
protoheme + H+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.98.1.1 | Candida albicans | - |
- |
- |
| 4.98.1.1 | Cryptococcus neoformans | Q5KFH8 | - |
- |
| 4.98.1.1 | Cryptococcus neoformans JEC21 | Q5KFH8 | - |
- |
| 4.98.1.1 | Neurospora crassa | - |
- |
- |
| 4.98.1.1 | Neurospora crassa FGSC 4200 | - |
- |
- |
| 4.98.1.1 | Phycomyces blakesleeanus | - |
- |
- |
| 4.98.1.1 | Phycomyces blakesleeanus NRRL1555 | - |
- |
- |
| 4.98.1.1 | Rhizopus arrhizus | - |
- |
- |
| 4.98.1.1 | Rhizopus arrhizus RA 99-880 | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.98.1.1 | protoporphyrin + Fe2+ | - |
Neurospora crassa | protoheme + H+ | - |
? | |
| 4.98.1.1 | protoporphyrin + Fe2+ | - |
Phycomyces blakesleeanus | protoheme + H+ | - |
? | |
| 4.98.1.1 | protoporphyrin + Fe2+ | - |
Rhizopus arrhizus | protoheme + H+ | - |
? | |
| 4.98.1.1 | protoporphyrin + Fe2+ | - |
Candida albicans | protoheme + H+ | - |
? | |
| 4.98.1.1 | protoporphyrin + Fe2+ | - |
Cryptococcus neoformans | protoheme + H+ | - |
? | |
| 4.98.1.1 | protoporphyrin + Fe2+ | - |
Phycomyces blakesleeanus NRRL1555 | protoheme + H+ | - |
? | |
| 4.98.1.1 | protoporphyrin + Fe2+ | - |
Rhizopus arrhizus RA 99-880 | protoheme + H+ | - |
? | |
| 4.98.1.1 | protoporphyrin + Fe2+ | - |
Neurospora crassa FGSC 4200 | protoheme + H+ | - |
? | |
| 4.98.1.1 | protoporphyrin + Fe2+ | - |
Cryptococcus neoformans JEC21 | protoheme + H+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.98.1.1 | HEM15 | - |
Neurospora crassa |
| 4.98.1.1 | HEM15 | - |
Phycomyces blakesleeanus |
| 4.98.1.1 | HEM15 | - |
Rhizopus arrhizus |
| 4.98.1.1 | HEM15 | - |
Candida albicans |
| 4.98.1.1 | HEM15 | - |
Cryptococcus neoformans |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 4.98.1.1 | Neurospora crassa | ferrochelatase is light-regulated in a white collar-dependent fashion, ferrochelatase transcript levels are higher after 1 h light exposure when compared with those of the strains grown in the dark | up |
| 4.98.1.1 | Phycomyces blakesleeanus | ferrochelatase is light-regulated in a white collar-dependent fashion, ferrochelatase transcript levels are higher after 1 h light exposure when compared with those of the strains grown in the dark | up |
| 4.98.1.1 | Rhizopus arrhizus | ferrochelatase is light-regulated in a white collar-dependent fashion, ferrochelatase transcript levels are higher after 1 h light exposure when compared with those of the strains grown in the dark | up |
| 4.98.1.1 | Candida albicans | ferrochelatase is light-regulated in a white collar-dependent fashion, ferrochelatase transcript levels are higher after 1 h light exposure when compared with those of the strains grown in the dark | up |
| 4.98.1.1 | Cryptococcus neoformans | ferrochelatase is light-regulated in a white collar-dependent fashion, ferrochelatase transcript levels are higher after 1 h light exposure when compared with those of the strains grown in the dark | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 4.98.1.1 | physiological function | HEM15 encodes a ferrochelatase that catalyses the final step in heme biosynthesis from highly photoreactive porphyrins. The enzyme is essential for viability | Neurospora crassa |
| 4.98.1.1 | physiological function | HEM15 encodes a ferrochelatase that catalyses the final step in heme biosynthesis from highly photoreactive porphyrins. The enzyme is essential for viability | Phycomyces blakesleeanus |
| 4.98.1.1 | physiological function | HEM15 encodes a ferrochelatase that catalyses the final step in heme biosynthesis from highly photoreactive porphyrins. The enzyme is essential for viability | Rhizopus arrhizus |
| 4.98.1.1 | physiological function | HEM15 encodes a ferrochelatase that catalyses the final step in heme biosynthesis from highly photoreactive porphyrins. The enzyme is essential for viability | Candida albicans |
| 4.98.1.1 | physiological function | HEM15 encodes a ferrochelatase that catalyses the final step in heme biosynthesis from highly photoreactive porphyrins. The enzyme is essential for viability | Cryptococcus neoformans |
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