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Literature summary extracted from

  • Schalow, B.J.; Courcelle, C.T.; Courcelle, J.
    Escherichia coli Fpg glycosylase is nonrendundant and required for the rapid global repair of oxidized purine and pyrimidine damage in vivo (2011), J. Mol. Biol., 410, 183-193.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.23 Escherichia coli
-
-
-
3.2.2.23 Escherichia coli SR108
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.23 DNA containing 4,6-diamino-5-formamidopyrimidine residues + H2O
-
 Escherichia coli DNA + 4,6-diamino-5-formamidopyrimidine
-
 ?
3.2.2.23 DNA containing 4,6-diamino-5-formamidopyrimidine residues + H2O
-
 Escherichia coli SR108 DNA + 4,6-diamino-5-formamidopyrimidine
-
 ?
3.2.2.23 DNA containing 5-hydroxycytosine residues + H2O
-
 Escherichia coli 5-hydroxycytosine + DNA
-
 ?
3.2.2.23 DNA containing 5-hydroxycytosine residues + H2O
-
 Escherichia coli SR108 5-hydroxycytosine + DNA
-
 ?
3.2.2.23 DNA containing 5-hydroxyuracil residues + H2O
-
 Escherichia coli 5-hydroxyuracil + DNA
-
 ?
3.2.2.23 DNA containing 5-hydroxyuracil residues + H2O
-
 Escherichia coli SR108 5-hydroxyuracil + DNA
-
 ?
3.2.2.23 DNA containing 8-oxoguanine residues + H2O
-
 Escherichia coli 8-oxoguanine + DNA
-
 ?
3.2.2.23 DNA containing 8-oxoguanine residues + H2O
-
 Escherichia coli SR108 8-oxoguanine + DNA
-
 ?
3.2.2.23 DNA containing dihydrothymine residues + H2O
-
 Escherichia coli dihydrothymine + DNA
-
 ?
3.2.2.23 additional information the enzyme is more active towards oxidized purines than oxidized pyrimidines and has little to no activity toward DNA containing thymine glycols and osmium-tetroxide-treated DNA Escherichia coli ?
-
 ?
3.2.2.23 additional information the enzyme is more active towards oxidized purines than oxidized pyrimidines and has little to no activity toward DNA containing thymine glycols and osmium-tetroxide-treated DNA Escherichia coli SR108 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.23 formamidopyrimidine-N-glycosylase
-
 Escherichia coli
3.2.2.23 FPG
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
3.2.2.23 physiological function the enzyme is nonrendundant and required for the rapid global repair of oxidized purine and pyrimidine damage in vivo. In vivo, the enzyme is required for the rapid removal its substrate lesions as well as a significant fraction of those recognized by endonuclease III, from the chromosome Escherichia coli