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Literature summary extracted from

  • Lewis, M.; Meza-Avina, M.E.; Wei, L.; Crandall, I.E.; Bello, A.M.; Poduch, E.; Liu, Y.; Paige, C.J.; Kain, K.C.; Pai, E.F.; Kotra, L.P.
    Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase (2011), J. Med. Chem., 54, 2891-2901.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.1.23 hanging drop vapor diffusion method Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.23 2'-deoxy-2'-fluoro-6-iodo-beta-D-uridine 5'-O-monophosphate
-
 Homo sapiens
4.1.1.23 2'-deoxy-2'-fluoro-6-iodo-beta-D-uridine 5'-O-monophosphate
-
 Methanothermobacter thermautotrophicus
4.1.1.23 2'-deoxy-2'-fluoro-6-iodo-UMP
-
 Homo sapiens
4.1.1.23 2'-deoxy-2'-fluoro-6-iodo-UMP
-
 Methanothermobacter thermautotrophicus
4.1.1.23 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl-cytosine
-
 Homo sapiens
4.1.1.23 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl-cytosine
-
 Methanothermobacter thermautotrophicus
4.1.1.23 5-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate
-
 Homo sapiens
4.1.1.23 5-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate
-
 Methanothermobacter thermautotrophicus
4.1.1.23 6-amido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate poor inhibitor Homo sapiens
4.1.1.23 6-amido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate poor inhibitor Methanothermobacter thermautotrophicus
4.1.1.23 6-amino-5-fluorouridine competitive inhibition at submicromolar concentrations Homo sapiens
4.1.1.23 6-amino-5-fluorouridine competitive inhibition at submicromolar concentrations Methanothermobacter thermautotrophicus
4.1.1.23 6-azauridine potent inhibitor Homo sapiens
4.1.1.23 6-azauridine potent inhibitor Methanothermobacter thermautotrophicus
4.1.1.23 6-azido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate
-
 Homo sapiens
4.1.1.23 6-azido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate
-
 Methanothermobacter thermautotrophicus
4.1.1.23 6-azido-5-fluorouridine irreversible inhibitor Homo sapiens
4.1.1.23 6-azido-5-fluorouridine irreversible inhibitor Methanothermobacter thermautotrophicus
4.1.1.23 6-azido-UMP
-
 Homo sapiens
4.1.1.23 6-azido-UMP
-
 Methanothermobacter thermautotrophicus
4.1.1.23 6-carbamoyl-UMP
-
 Methanothermobacter thermautotrophicus
4.1.1.23 6-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate reversible inhibitor Homo sapiens
4.1.1.23 6-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate reversible inhibitor Methanothermobacter thermautotrophicus
4.1.1.23 6-cyanouridine
-
 Homo sapiens
4.1.1.23 6-cyanouridine
-
 Methanothermobacter thermautotrophicus
4.1.1.23 6-hydroxyuridine potent inhibitor Homo sapiens
4.1.1.23 6-hydroxyuridine potent inhibitor Methanothermobacter thermautotrophicus
4.1.1.23 6-iodouridine
-
 Homo sapiens
4.1.1.23 6-iodouridine
-
 Methanothermobacter thermautotrophicus
4.1.1.23 6-thiocarboxamidouridine potent inhibitor Homo sapiens
4.1.1.23 6-thiocarboxamidouridine potent inhibitor Methanothermobacter thermautotrophicus
4.1.1.23 clevudine
-
 Homo sapiens
4.1.1.23 clevudine
-
 Methanothermobacter thermautotrophicus
4.1.1.23 gemcitabine
-
 Homo sapiens
4.1.1.23 gemcitabine
-
 Methanothermobacter thermautotrophicus
4.1.1.23 nifedipine competitive inhibitor Homo sapiens
4.1.1.23 nifedipine competitive inhibitor Methanothermobacter thermautotrophicus
4.1.1.23 nimodipine competitive inhibitor Homo sapiens
4.1.1.23 nimodipine competitive inhibitor Methanothermobacter thermautotrophicus
4.1.1.23 pyrazofurin potent inhibitor Homo sapiens
4.1.1.23 pyrazofurin potent inhibitor Methanothermobacter thermautotrophicus
4.1.1.23 Xanthosine potent inhibitor Homo sapiens
4.1.1.23 Xanthosine potent inhibitor Methanothermobacter thermautotrophicus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.23 Homo sapiens
-
-
-
4.1.1.23 Methanothermobacter thermautotrophicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.23 Orotidine 5'-phosphate
-
 Homo sapiens UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate
-
 Methanothermobacter thermautotrophicus UMP + CO2
-
 ?
4.1.1.23 orotidine 5'-phosphate + H+
-
 Homo sapiens UMP + CO2
-
 ?
4.1.1.23 orotidine 5'-phosphate + H+
-
 Methanothermobacter thermautotrophicus UMP + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.23 ODCase
-
 Homo sapiens
4.1.1.23 ODCase
-
 Methanothermobacter thermautotrophicus
4.1.1.23 OMPDCase
-
 Homo sapiens
4.1.1.23 OMPDCase
-
 Methanothermobacter thermautotrophicus
4.1.1.23 Orotidine 5'-monophosphate decarboxylase
-
 Homo sapiens
4.1.1.23 Orotidine 5'-monophosphate decarboxylase
-
 Methanothermobacter thermautotrophicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.1.23 0.00132
-
 6-carbamoyl-UMP in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Methanothermobacter thermautotrophicus
4.1.1.23 0.0286
-
 6-cyanouridine in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Methanothermobacter thermautotrophicus
4.1.1.23 0.037
-
 6-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Methanothermobacter thermautotrophicus
4.1.1.23 0.204
-
 6-cyanouridine in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Homo sapiens
4.1.1.23 0.36
-
 5-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Methanothermobacter thermautotrophicus
4.1.1.23 0.759
-
 5-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Homo sapiens
4.1.1.23 2
-
 6-cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate Ki above 2 mM, in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Homo sapiens
4.1.1.23 3.322
-
 6-amido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Methanothermobacter thermautotrophicus
4.1.1.23 4
-
 6-amido-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-monophosphate Ki above 4 mM, in 50 mM Tris, pH 7.5, 20 mM dithiothreitol, and 40 mM NaCl, at 55°C Homo sapiens