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Literature summary extracted from

  • Bu, S.Y.; Mashek, D.G.
    Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways (2010), J. Lipid Res., 51, 3270-3280.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.3 ACSl5, quantitative real-time PCR expression analysis Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
6.2.1.3 additional information siRNA knockdown of ACSL5 in rat primary hepatocytes Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.3 ATP + octadecanoate + CoA Rattus norvegicus
-
 AMP + diphosphate + octadecanoyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Rattus norvegicus O88813 isozyme ACSL5
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.3 liver
-
 Rattus norvegicus
-
6.2.1.3 additional information ACSL5 is expressed predominantly in tissues with high rates of triacylglycerol synthesis Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.3 ATP + octadecanoate + CoA
-
 Rattus norvegicus AMP + diphosphate + octadecanoyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.3 ACSL5
-
 Rattus norvegicus
6.2.1.3 long-chain acyl-CoA synthetase 5
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.3 ATP
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
6.2.1.3 malfunction suppression of ACSL5 expression significantly decreases fatty acid-induced lipid droplet formation. ACSL5 knockdown results in decreased oleic acid or acetic acid incorporation into intracellular triacylglycerol, phospholipids, and cholesterol esters without altering fatty acid uptake or lipogenic gene expression. ACSL5 knockdown also decreases hepatic TAG secretion proportionate to the observed decrease in neutral lipid synthesis. ACSL5 knockdown does not alter lipid turnover or mediate the effects of insulin on lipid metabolism, phenotype, detailed overview Rattus norvegicus
6.2.1.3 physiological function ACSL5 may have an anabolic role in lipid metabolism Rattus norvegicus