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Literature summary extracted from

  • Wang, C.; Chen, S.; Wang, X.; Wang, L.; Wallis, A.K.; Freedman, R.B.; Wang, C.C.
    Plasticity of human protein disulfide isomerase: evidence for mobility around the X-linker region and its functional significance (2010), J. Biol. Chem., 285, 26788-26797.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.4.1
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
5.3.4.1 I272A the mutant shows similar proteinase K sensitivity like the wild type protein. The mutant shows significantly lower potency than wild type PDI in suppressing aggregation of denatured rhodanese Homo sapiens
5.3.4.1 L343A the mutant is more sensitive to proteinase K than wild type enzyme. The mutant shows the same chaperone activity as that of wild type PDI Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.4.1 endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

EC Number Organism UniProt Comment Textmining
5.3.4.1 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.4.1 denatured rhodanese PDI exhibits chaperone activity with rhodanese Homo sapiens ?
-
 ?
5.3.4.1 insulin PDI exhibits reductase activity with insulin Homo sapiens ?
-
 ?
5.3.4.1 RNase A PDI exhibits isomerase activity with RNase A Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.4.1 PDI
-
 Homo sapiens
5.3.4.1 protein disulfide isomerase
-
 Homo sapiens