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Literature summary extracted from

  • Mikolajczyk, J.; Drag, M.; Bekes, M.; Cao, J.T.; Ronai, Z.; Salvesen, G.S.
    Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs (2007), J. Biol. Chem., 282, 26217-26224.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.B71 SUMO SUMO domain enhances catalysis of SENP2, substrate induced activation Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.22.B71 expression of catalytic domains of SENP2 in Escherichia coli BL21 (DE3) as N-terminal His-tagged proteins Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.B71 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.B71 catalytic domains of SENP2 expressed in Escherichia coli BL21 (DE3) as N-terminal His-tagged proteins Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.B71 brain brain Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.B71 acetyl-QTGG-7-amino-4-trifluoromethylcoumarin + H2O
-
 Homo sapiens acetyl-QTGG + 7-amino-4-trifluoromethylcoumarin
-
 ?
3.4.22.B71 SUMO-1 precursor + H2O very low isopeptidase activity with SUMO-1. SENP2 exhibits substantially higher isopeptidase than endopeptidase activity Homo sapiens SUMO-1 + His-Ser-Thr-Val
-
 ?
3.4.22.B71 SUMO-2 precursor + H2O SENP2 exhibits substantially higher isopeptidase than endopeptidase activity Homo sapiens SUMO-2 + Val-Tyr
-
 ?
3.4.22.B71 SUMO-3 precursor + H2O SENP2 exhibits substantially higher isopeptidase than endopeptidase activity Homo sapiens SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
-
 ?
3.4.22.B71 SUMO-Ran GTPase-activating protein 1 conjugate + H2O SENP2 exhibits substantially higher isopeptidase than endopeptidase activity Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.B71 SENP2
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.B71 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.B71 8.5
-
-
 Homo sapiens