Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Bertrand, T.; Eady, N.A.; Jones, J.N.; Jesmin, J.N.; Nagy, J.M.; Jamart-Gregoire, B.; Raven, E.L.; Brown, K.A.
    Crystal structure of Mycobacterium tuberculosis catalase-peroxidase (2004), J. Biol. Chem., 279, 38991-38999.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.11.1.21 medicine catalase-peroxidase activates the core anti-tuberculosis drug isoniazid Mycobacterium tuberculosis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.11.1.21 expressed in Escherichia coli strain UM255 Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.11.1.21 hanging drop vapor diffusion method, using 4% (w/v) polyethylene glycol 3350 and 0.1 M sodium acetate (pH 4.6), at 20°C Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.21 Mycobacterium tuberculosis P9WIE5
-
-
1.11.1.21 Mycobacterium tuberculosis H37Rv P9WIE5
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.11.1.21 DEAE-Sepharose column chromatography, Superdex 200 gel filtration, and Resource Q column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.21 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2
-
 Mycobacterium tuberculosis oxidized 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O
-
 ?
1.11.1.21 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O2
-
 Mycobacterium tuberculosis H37Rv oxidized 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) + H2O
-
 ?
1.11.1.21 H2O2
-
 Mycobacterium tuberculosis O2 + H2O
-
 ?
1.11.1.21 H2O2
-
 Mycobacterium tuberculosis H37Rv O2 + H2O
-
 ?
1.11.1.21 o-dianisidine + H2O2
-
 Mycobacterium tuberculosis oxidized o-dianisidine + H2O
-
 ?
1.11.1.21 o-dianisidine + H2O2
-
 Mycobacterium tuberculosis H37Rv oxidized o-dianisidine + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.11.1.21 homodimer x-ray crystallography Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.1.21 heme a heme-dependent enzyme Mycobacterium tuberculosis