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Literature summary extracted from

  • Kakuma, T.; Nishida, J.; Tsuzuki, T.;, Sekiguchi, M.
    Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution (1995), J. Biol. Chem., 270, 25942-25948.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.56 expressed in Escherichia coli mutT2 mutant cells devoid of their own 8-oxo-dGTPase activity Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.6.1.56 17896
-
 x * 17896, calculated from sequence Mus musculus
3.6.1.56 18000
-
 x * 18000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.56 8-oxo-dGTP + H2O Mus musculus 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP) is formed in the nucleotide pool of a cell during normal cellular metabolism, and when it is incorporated into DNA causes mutation. Organisms possess 8-oxo-dGTPase, an enzyme that specifically degrades 8-oxo-dGTP to 8-oxo-dGMP. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP 8-oxo-dGMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.56 Mus musculus P53368
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.56 embryonic stem cell high level of activity Mus musculus
-
3.6.1.56 large intestine high level of activity Mus musculus
-
3.6.1.56 liver high level of activity Mus musculus
-
3.6.1.56 thymus high level of activity Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.56 8-oxo-dGTP + H2O 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP) is formed in the nucleotide pool of a cell during normal cellular metabolism, and when it is incorporated into DNA causes mutation. Organisms possess 8-oxo-dGTPase, an enzyme that specifically degrades 8-oxo-dGTP to 8-oxo-dGMP. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP Mus musculus 8-oxo-dGMP + diphosphate
-
 ?
3.6.1.56 8-oxo-dGTP + H2O 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP Mus musculus 8-oxo-dGMP + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.6.1.56 ? x * 18000, SDS-PAGE Mus musculus
3.6.1.56 ? x * 17896, calculated from sequence Mus musculus