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Literature summary extracted from

  • Henry, J.; Guillotte, A.; Luberto, C.; Del Poeta, M.
    Characterization of inositol phospho-sphingolipid-phospholipase C 1 (Isc1) in Cryptococcus neoformans reveals unique biochemical features (2011), FEBS Lett., 585, 635-640.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.11 expression of sc1 in Saccharomyces cerevisiae DELTAisc1 mutant Cryptococcus neoformans

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.11 D114A catalytically inactive Isc1 mutant Cryptococcus neoformans
3.1.4.11 K119A catalytically inactive Isc1 mutant Cryptococcus neoformans
3.1.4.11 additional information Isc1, site-directed mutagenesis of the P-loop-like domain Cryptococcus neoformans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.11 additional information Cryptococcus neoformans Isc1 only exerts IPC-PLC activity ?
-
 ?
3.1.4.11 additional information Cryptococcus neoformans H99 Isc1 only exerts IPC-PLC activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.11 Cryptococcus neoformans
-
 serotype C
-
3.1.4.11 Cryptococcus neoformans
-
 var. gattii serotype B
-
3.1.4.11 Cryptococcus neoformans
-
 var. grubii serotype A
-
3.1.4.11 Cryptococcus neoformans H99
-
 serotype C
-
3.1.4.11 Cryptococcus neoformans H99
-
 var. gattii serotype B
-
3.1.4.11 Cryptococcus neoformans H99
-
 var. grubii serotype A
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.11 additional information Isc1 only exerts IPC-PLC activity Cryptococcus neoformans ?
-
 ?
3.1.4.11 additional information Isc1 only exerts IPC-PLC activity Cryptococcus neoformans H99 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.11 inositol phosphosphingolipid-phospholipase C
-
 Cryptococcus neoformans
3.1.4.11 IPC-PLC
-
 Cryptococcus neoformans
3.1.4.11 Isc1
-
 Cryptococcus neoformans

General Information

EC Number General Information Comment Organism
3.1.4.11 physiological function Isc1 regulates the level of complex sphingolipids and certain species of phytoceramide, especially when fungal cells are exposed to acidic stress. Either the enzyme Isc1 P-loop is not involved in the substrate recognition or that it is not sufficient to discriminate between phosphoinositide and sphingomyelin Cryptococcus neoformans