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Literature summary extracted from

  • Ito, M.; Toyoda, N.; Nomura, E.; Takamura, Y.; Amino, N.; Iwasaka, T.; Takamatsu, J.; Miyauchi, A.; Nishikawa, M.
    Type 1 and type 2 iodothyronine deiodinases in the thyroid gland of patients with 3,5,3'-triiodothyronine-predominant Graves' disease (2011), Eur. J. Endocrinol., 164, 95-100.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.21.99.4 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.4 thyroid gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.4 L-thyroxine + AH2
-
 Homo sapiens 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.99.4 DIO1
-
 Homo sapiens
1.21.99.4 DIO2
-
 Homo sapiens
1.21.99.4 type 1 iodothyronine deiodinase
-
 Homo sapiens
1.21.99.4 type 2 iodothyronine deiodinase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.21.99.4 dithioerythritol
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.21.99.4 Homo sapiens there is no significant difference between the thyroidal type 2 iodothyronine deiodinase mRNA level in patients with with 3,5,3'-triiodothyronine-predominant Graves' disease and that in patients with common type-Graves' disease additional information
1.21.99.4 Homo sapiens thyroidal type 1 iodothyronine deiodinase mRNA level and activity in patients with 3,5,3'-triiodothyronine-predominant Graves' disease is significantly higher than that in patients with common type-Graves' disease up