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Literature summary extracted from

  • Akeno, N.; Saikatsu, S.; Kawane, T.; Horiuchi, N.
    Mouse vitamin D-24-hydroxylase: molecular cloning, tissue distribution, and transcriptional regulation by 1alpha,25-dihydroxyvitamin D3 (1997), Endocrinology, 138, 2233-2240.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.15.16 55450
-
 mature enzyme, calculated from amino acid sequence Mus musculus
1.14.15.16 59500
-
 calculated from amino acid sequence Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.16 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.16 bone
-
 Mus musculus
-
1.14.15.16 colon
-
 Mus musculus
-
1.14.15.16 duodenum
-
 Mus musculus
-
1.14.15.16 heart
-
 Mus musculus
-
1.14.15.16 ileum
-
 Mus musculus
-
1.14.15.16 intestine highest mRNA expression Mus musculus
-
1.14.15.16 jejunum
-
 Mus musculus
-
1.14.15.16 kidney highest mRNA expression Mus musculus
-
1.14.15.16 lung
-
 Mus musculus
-
1.14.15.16 pancreas
-
 Mus musculus
-
1.14.15.16 skin
-
 Mus musculus
-
1.14.15.16 spleen
-
 Mus musculus
-
1.14.15.16 testis
-
 Mus musculus
-
1.14.15.16 thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.16 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Mus musculus 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1.14.15.16 25-hydroxyvitamin D3 + NADPH + H+ + O2
-
 Mus musculus 24R,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.16 24-OHase
-
 Mus musculus
1.14.15.16 vitamin D-24-hydroxylase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.16 NADPH
-
 Mus musculus

Expression

EC Number Organism Comment Expression
1.14.15.16 Mus musculus intraperitoneal injection of 1,25-dihydroxyvitamin D3 induces dose- and time-dependent increases in both 24-OHase mRNA abundance and enzyme activity in mouse kidney reaching a maximum between 4-8 h, after which it decreases and then maintains a steady value between 18-72 h. Similarly, 1,25-dihydroxyvitamin D3-induced increases in both 24-OHase mRNA and activity are apparent in the duodenum. Although 1,25-dihydroxyvitamin D3 markedly the amount of 24-OHase mRNA in skin between 4 and 6 h, enzyme activity is not detected in this tissue. Pretreatment of mice with cycloheximide (0.4mg/g) potentiates the increase in 24-OHase mRNA abundance but blocks the increase in 24-OHase activity, induced by 1,25-dihydroxyvitamin D3 in kidney and duodenum up