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Literature summary extracted from

  • Tenenhouse, H.S.; Jones, G.
    Effect of the X-linked Hyp mutation and vitamin D status on induction of renal 25-hydroxyvitamin D3-24-hydroxylase (1987), Endocrinology, 120, 609-616.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.15.16 1alpha,25-dihydroxyvitamin D3 renal 24-hydroxylase is significantly stimulated by 1alpha,25-dihydroxyvitamin D3 treatment in both normal and Hyp mice. In normal mice, 1alpha,25-dihydroxyvitamin D3 treatment is more effective than calcium in turning on 24-hydroxylase activity. In Hyp mice, treatment with calcium plus 1alpha,25-dihydroxyvitamin D3 results in a greater increase in 24-hydroxylase than treatment with either agent alone. 24-hydroxylase is 3fold, and 8fold greater in Hyp mice relative to normal treated with 1alpha,25-dihydroxyvitamin D3, and calcium plus 1alpha,25-dihydroxyvitamin D3, respectively Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.15.16 Ca2+ 24-hydroxylase activity is 20fold greater in Hyp mice relative to normal treated with calcium. In Hyp mice, treatment with calcium plus 1alpha,25-dihydroxyvitamin D3 results in a greater increase in 24-hydroxylase than treatment with either agent alone Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.16 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.16 kidney
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.16 25-hydroxyvitamin D3 + NADPH + H+ + O2
-
 Mus musculus secalciferol + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.16 24-hydroxylase
-
 Mus musculus
1.14.15.16 25-hydroxyvitamin D-24-hydroxylase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.16 NADPH
-
 Mus musculus