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Literature summary extracted from

  • Cincinelli, A.; Martellini, T.; Innocenti, A.; Scozzafava, A.; Supuran, C.T.
    Purification and inhibition studies with anions and sulfonamides of an alpha-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii (2011), Bioorg. Med. Chem., 19, 1847-1851.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 acetazolamide
-
 Leptonychotes weddellii
4.2.1.1 azide
-
 Leptonychotes weddellii
4.2.1.1 benzolamide
-
 Leptonychotes weddellii
4.2.1.1 bicarbonate high inhibition Leptonychotes weddellii
4.2.1.1 brinzolamide
-
 Leptonychotes weddellii
4.2.1.1 bromide
-
 Leptonychotes weddellii
4.2.1.1 Carbonate high inhibition Leptonychotes weddellii
4.2.1.1 chloride
-
 Leptonychotes weddellii
4.2.1.1 Cyanate high inhibition Leptonychotes weddellii
4.2.1.1 cyanide high inhibition Leptonychotes weddellii
4.2.1.1 dichlorophenamide
-
 Leptonychotes weddellii
4.2.1.1 dorzolamide
-
 Leptonychotes weddellii
4.2.1.1 fluoride
-
 Leptonychotes weddellii
4.2.1.1 H2NSO2NH2
-
 Leptonychotes weddellii
4.2.1.1 H2NSO3H
-
 Leptonychotes weddellii
4.2.1.1 HSO3-
-
 Leptonychotes weddellii
4.2.1.1 hydrochlorothiazide
-
 Leptonychotes weddellii
4.2.1.1 Iodide
-
 Leptonychotes weddellii
4.2.1.1 methazolamide
-
 Leptonychotes weddellii
4.2.1.1 additional information no inhibition by perchlorate Leptonychotes weddellii
4.2.1.1 nitrate
-
 Leptonychotes weddellii
4.2.1.1 nitrite
-
 Leptonychotes weddellii
4.2.1.1 PhAsO3H2
-
 Leptonychotes weddellii
4.2.1.1 PhB(OH)2
-
 Leptonychotes weddellii
4.2.1.1 saccharin
-
 Leptonychotes weddellii
4.2.1.1 sulfamate
-
 Leptonychotes weddellii
4.2.1.1 sulfamide high inhibition Leptonychotes weddellii
4.2.1.1 sulfate
-
 Leptonychotes weddellii
4.2.1.1 Sulfide
-
 Leptonychotes weddellii
4.2.1.1 thiocyanate high inhibition Leptonychotes weddellii
4.2.1.1 zonisamide
-
 Leptonychotes weddellii

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.1 Zn2+ catalytically crucial Leptonychotes weddellii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.1.1 30000
-
 x * 30000, about, SDS-PAGE Leptonychotes weddellii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.1 H2CO3 Leptonychotes weddellii
-
 CO2 + H2O
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Leptonychotes weddellii
-
 adult female Weddell seals
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.1 heart
-
 Leptonychotes weddellii
-
4.2.1.1 intestine
-
 Leptonychotes weddellii
-
4.2.1.1 kidney
-
 Leptonychotes weddellii
-
4.2.1.1 liver
-
 Leptonychotes weddellii
-
4.2.1.1 lung
-
 Leptonychotes weddellii
-
4.2.1.1 spleen
-
 Leptonychotes weddellii
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 H2CO3
-
 Leptonychotes weddellii CO2 + H2O
-
 r

Subunits

EC Number Subunits Comment Organism
4.2.1.1 ? x * 30000, about, SDS-PAGE Leptonychotes weddellii

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 alpha-carbonic anhydrase
-
 Leptonychotes weddellii
4.2.1.1 lwCA
-
 Leptonychotes weddellii

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.2.1.1 20
-
 assay at Leptonychotes weddellii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.1.1 7.5
-
 assay at Leptonychotes weddellii

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.2.1.1 0.046
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii PhB(OH)2
4.2.1.1 0.055
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii H2NSO3H
4.2.1.1 0.057
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii PhAsO3H2
4.2.1.1 0.06
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii Carbonate
4.2.1.1 0.07
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii cyanide
4.2.1.1 0.07
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii H2NSO2NH2
4.2.1.1 0.087
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii Cyanate
4.2.1.1 0.097
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii thiocyanate
4.2.1.1 0.1
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii bicarbonate
4.2.1.1 0.59
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii HSO3-
4.2.1.1 0.74
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii fluoride
4.2.1.1 0.82
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii sulfate
4.2.1.1 0.83
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii azide
4.2.1.1 0.89
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii chloride
4.2.1.1 0.9
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii nitrite
4.2.1.1 1
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii Sulfide
4.2.1.1 1.01
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii bromide
4.2.1.1 20
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii Iodide
4.2.1.1 55.6
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii nitrate