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Literature summary extracted from

  • Kuhn, I.; Kellenberger, E.; Said-Hassane, F.; Villa, P.; Rognan, D.; Lobstein, A.; Haiech, J.; Hibert, M.; Schuber, F.; Muller-Steffner, H.
    Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme (2010), Bioorg. Med. Chem., 18, 7900-7910.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.2.5 expressed in Pichia pastoris Schistosoma mansoni

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.2.5 cyanidin
-
 Schistosoma mansoni
3.2.2.5 delphinidin
-
 Schistosoma mansoni
3.2.2.5 diosmetinidin
-
 Schistosoma mansoni
3.2.2.5 fisetinidin
-
 Schistosoma mansoni
3.2.2.5 kuromanin
-
 Schistosoma mansoni
3.2.2.5 luteolin
-
 Schistosoma mansoni
3.2.2.5 luteolinidin
-
 Schistosoma mansoni
3.2.2.5 malvidin
-
 Schistosoma mansoni
3.2.2.5 additional information not inhibited by rac-catechin, piceatannol, trans-resveratrol, praziquantel, cucurmin, chloroquine, mefloquine, Cibacron Blue 3GA, PJ-34, and 1,8-naphthalimide Schistosoma mansoni
3.2.2.5 myricetin
-
 Schistosoma mansoni
3.2.2.5 pelargonidin
-
 Schistosoma mansoni
3.2.2.5 peonidin
-
 Schistosoma mansoni
3.2.2.5 petunidin
-
 Schistosoma mansoni
3.2.2.5 quercetagetin
-
 Schistosoma mansoni
3.2.2.5 quercetagetinidin
-
 Schistosoma mansoni
3.2.2.5 quercetin
-
 Schistosoma mansoni
3.2.2.5 rac-taxifolin
-
 Schistosoma mansoni
3.2.2.5 robinetin
-
 Schistosoma mansoni

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.5 Schistosoma mansoni
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.2.5 Blue Sepharose column chromatography, gel filtration Schistosoma mansoni

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.2.5 integument
-
 Schistosoma mansoni
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.5 1,N6-etheno NAD+ + H2O
-
 Schistosoma mansoni epsilon-ADP-ribose + nicotinamide + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.5 NACE
-
 Schistosoma mansoni
3.2.2.5 NAD+ catabolizing enzyme
-
 Schistosoma mansoni
3.2.2.5 NAD+glycohydrolase
-
 Schistosoma mansoni

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.2.5 0.0013
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni quercetagetin
3.2.2.5 0.0023
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni cyanidin
3.2.2.5 0.0039
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni quercetin
3.2.2.5 0.0044
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni pelargonidin
3.2.2.5 0.0056
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni peonidin
3.2.2.5 0.0058
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni robinetin
3.2.2.5 0.0059
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni luteolinidin
3.2.2.5 0.006
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni delphinidin
3.2.2.5 0.0061
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni quercetagetinidin
3.2.2.5 0.0064
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni fisetinidin
3.2.2.5 0.008
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni malvidin
3.2.2.5 0.0082
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni kuromanin
3.2.2.5 0.0084
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni luteolin
3.2.2.5 0.0099
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni diosmetinidin
3.2.2.5 0.0195
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni rac-taxifolin
3.2.2.5 0.022
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni myricetin
3.2.2.5 0.0378
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogen Schistosoma mansoni petunidin