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Literature summary extracted from

  • Hu, L.; Hu, H.; Wu, W.; Chai, X.; Luo, J.; Wu, Q.
    Discovery of novel xanthone derivatives as xanthine oxidase inhibitors (2011), Bioorg. Med. Chem. Lett., 21, 4013-4015.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 1,3,6,7-tetrahydroxy-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 1-[(2,4-dichlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 1-[(2,6-dichlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 1-[(2-bromobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 1-[(2-chlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 1-[(2-fluorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 1-[(3-bromobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 1-[(3-chlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 1-[(3-fluorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 1-[(4-bromobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 1-[(4-chlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 1-[(4-fluorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 2-[[(3,6,7-trihydroxy-9-oxo-9H-xanthen-1-yl)oxy]methyl]benzonitrile
-
 Bos taurus
1.17.3.2 3,6,7-trihydroxy-1-[(2-methylbenzyl)oxy]-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 3,6,7-trihydroxy-1-[(2-nitrobenzyl)oxy]-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 3,6,7-trihydroxy-1-[(3-methylbenzyl)oxy]-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 3,6,7-trihydroxy-1-[(3-nitrobenzyl)oxy]-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 3,6,7-trihydroxy-1-[(4-methylbenzyl)oxy]-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 3,6,7-trihydroxy-1-[(4-nitrobenzyl)oxy]-9H-xanthen-9-one
-
 Bos taurus
1.17.3.2 3-[[(3,6,7-trihydroxy-9-oxo-9H-xanthen-1-yl)oxy]methyl]benzonitrile
-
 Bos taurus
1.17.3.2 4-[[(3,6,7-trihydroxy-9-oxo-9H-xanthen-1-yl)oxy]methyl]benzonitrile
-
 Bos taurus
1.17.3.2 additional information xanthone derivatives as xanthine oxidase inhibitors, synthesis of a series of xanthone derivatives, overview. No inhibition by 8d, 8e, 8f, 8h, 8j, 8k, 8m, 8n, 8o, 8p, 8q, 8s, and 8t Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.3.2 extracellular
-
 Bos taurus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 milk
-
 Bos taurus
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.17.3.2 0.00467
-
 pH not specified in the publication, temperature not specified in the publication Bos taurus 4-[[(3,6,7-trihydroxy-9-oxo-9H-xanthen-1-yl)oxy]methyl]benzonitrile
1.17.3.2 0.0047
-
 pH not specified in the publication, temperature not specified in the publication Bos taurus 1-[(4-chlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
1.17.3.2 0.00573
-
 pH not specified in the publication, temperature not specified in the publication Bos taurus 3,6,7-trihydroxy-1-[(4-methylbenzyl)oxy]-9H-xanthen-9-one
1.17.3.2 0.00641
-
 pH not specified in the publication, temperature not specified in the publication Bos taurus 1-[(2-chlorobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
1.17.3.2 0.00708
-
 pH not specified in the publication, temperature not specified in the publication Bos taurus 3,6,7-trihydroxy-1-[(2-methylbenzyl)oxy]-9H-xanthen-9-one
1.17.3.2 0.01356
-
 pH not specified in the publication, temperature not specified in the publication Bos taurus 3,6,7-trihydroxy-1-[(3-methylbenzyl)oxy]-9H-xanthen-9-one
1.17.3.2 0.02006
-
 pH not specified in the publication, temperature not specified in the publication Bos taurus 1-[(4-bromobenzyl)oxy]-3,6,7-trihydroxy-9H-xanthen-9-one
1.17.3.2 0.02173
-
 pH not specified in the publication, temperature not specified in the publication Bos taurus 1,3,6,7-tetrahydroxy-9H-xanthen-9-one

General Information

EC Number General Information Comment Organism
1.17.3.2 metabolism xanthine oxidase is the key enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid Bos taurus